Genomic 5-mC contents in peripheral blood leukocytes were independent protective factors for coronary artery disease with a specific profile in different leukocyte subtypes

Table 5 Characteristics of case and control subgroups in PBL subtype analysis

Clinical data	Control (n = 50)	Case^a (n = 50)	P
Age (years)	64 ± 9.5	62 ± 9.9	0.248^b
Male gender	26 (52%)	27 (54%)	0.84^c
Hypertension	16 (32%)	31 (62%)	0.003 ^c
Hyperlipidemia	9 (18%)	19 (38%)	0.026 ^c,d
Diabetes	10 (20%)	21 (42%)	0.017 ^c
PBLs counts (10 ⁹ /L)	5.48 (4.56~6.65)	6.63 (5.63~9.28)	0.001 ^e
Neutrophil (%)	59.22 ± 10.55	66.01 ± 11.45	0.003 ^b
Lymphocyte (%)	30.28 ± 8.46	24.08 ± 9.72	0.001 ^b
Monocyte (%)	7.72 ± 2.78	7.47 ± 2.47	0.625^b
5-mC contents (5-mC/C %)	4.11 ± 0.73	3.75 ± 0.76	0.017 ^b
5-hmC contents (5-hmC/C %)	0.0163 ± 0.0052	0.0191 ± 0.0048	0.005 ^b
DNMT1 expressions	0.0084 ± 0.0058	0.0064 ± 0.0029	0.006 ^b

Data are presented as mean ± SD or as median (inter-quartile range). Italic letters show the significant associations and their P values
^aThe CAD patients are consists of 14 (28%) myocardial infarction and 36 (72%) angina pectoris, respectively
^bStudent’s t test
^cχ² test
^dMost of the CAD patients with hyperlipidemia were under anti-hyperlipidemia therapy in the case group
^eMann-Whitney U test

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