Genomic 5-mC contents in peripheral blood leukocytes were independent protective factors for coronary artery disease with a specific profile in different leukocyte subtypes

Table 1 Characteristics of cases and controls in association analysis

Clinical data	Control (n = 270)	Case^a (n = 265)	P
Age (years)	57.72 ± 10	58.03 ± 9.5	0.716^b
Male gender	150 (56%)	154 (58%)	0.601^c
Hypertension	93 (34%)	169 (64%)	< 0.001 ^c
Hyperlipidemia	63 (23%)	100 (38%)	< 0.001 ^c
Diabetes	66 (24%)	106 (40%)	< 0.001 ^c
TC (mmol/L)	4.36 ± 0.55	4.37 ± 1.07	0.832^b,d
TG (mmol/L)	1.01 (0.77~1.28)	1.35 (1.00~1.92)	< 0.001 ^d,e
HDL-C (mmol/L)	1.26 (1.13~1.42)	1.10 (0.94~1.34)	< 0.001 ^d,e
LDL-C (mmol/L)	2.57 ± 0.36	2.43 ± 0.88	0.017 ^b,d
FBG (mmol/L)	4.71 (4.35~5.15)	5.84 (5.31~6.87)	< 0.001 ^e
PBLs counts (10 ⁹ /L)	5.30 (4.60~6.29)	6.58 (5.33~7.92)	< 0.001 ^e
PBLs classifications (PBMCs %)	40.31 ± 8.11	34.48 ± 10.16	< 0.001 ^b
5-mC contents (5-mC/C %)	4.42 ± 0.87	3.90 ± 0.63	< 0.001 ^b,f

Data are presented as mean ± SD or as median (inter-quartile range). Italic letters show the significant associations and their P values. PBL classifications were calculated by percentages of PBMCs in PBLs
^aThe CAD patients are consists of 71 (27%) myocardial infarction and 194 (73%) angina pectoris, respectively
^bStudent’s t test
^cχ² test
^dMost of the CAD patients with hyperlipidemia were under anti-hyperlipidemia therapy in the case group
^eMann-Whitney U test
^fP = 1.10 × 10^− 14

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