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Fig. 8 | Clinical Epigenetics

Fig. 8

From: Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

Fig. 8

Novel clinical parameter in block-and-lock strategy to induce HIV-1 latency. The figure shows the ongoing viral replication from active HIV-1 reservoirs (left side) and how LPAs promote HIV-1 latency and suppress viral reactivation (enlargement). Panels a and b are schematic diagram of novel block-and-lock strategy with various degree impacts of PIs and non-PIs on the induction of viral latency. a Illustrates the suppression of HIV-1 replication by LPAs together with PIs. The presence of PIs and Akt inhibitors in the standard cART regimen inhibit the Akt signaling which in turn synergistically enhance EZH2-mediated H3K27me3 and HIV-1 latency. b Illustrates HIV-1 latency in the presence of cART containing non-PIs. Akt phosphorylates EZH2 and BMI1 at Ser 21 and Ser 316, respectively. It impairs their functions which results in decreased H3K27me3 and H2A ub and weakly suppresses HIV-1 from its latent reservoirs

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