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Table 2 Results of linear regression analyses of measures of walking and sedentary behavior according to epigenetic age acceleration estimates at age 79

From: The epigenetic clock and objectively measured sedentary and walking behavior in older adults: the Lothian Birth Cohort 1936

 

Regression coefficient (95% CI) and P values2

Epigenetic age acceleration measures, per year increase

Percent of time spent sedentary

Logged average number of steps per day

Logged average number of sit-to-stand transitions per day

Extrinsic epigenetic age acceleration

Adjusted for sex and age

0.181 (− 0.025, 0.387)

P = 0.085/P corrected = 0.187

− 0.100 (− 0.008, − 0.001)

P = 0.027/P corrected = 0.149

− 0.001 (− 0.006, 0.004)

P = 0.671/P corrected = 0.671

Multivariable-adjusted1

0.109 (− 0.093, 0.310)

P = 0.289/P corrected = 0.397

− 0.007 (− 0.015, 0.001)

P = 0.083/P corrected = 0.187

− 0.003 (− 0.006, 0.005)

P = 0.922/P corrected = 0.920

Intrinsic epigenetic age acceleration

Adjusted for sex and age

− 0.105 (− 0.340, 0.129)

P = 0.379/P corrected = 0.429

− 0.005 (− 0.015, 0.004)

P = 0.273/P corrected = 0.397

0.006 (0.0001, 0.012)

P = 0.049/P corrected = 0.181

Multivariable-adjusted1

− 0.146 (− 0.371, 0.079)

P = 0.203/P corrected = 0.372

− 0.004 (− 0.013, 0.005)

P = 0.390/P corrected = 0.429

0.007 (0.001, 0.013)

P = 0.027/P corrected = 0.149

  1. 1Adjusted for age, sex, body mass index, depression score, and number of chronic physical illnesses.
  2. 2P values are shown uncorrected and with correction for the false discovery rate