Table 3 Summary of epigenetic events in the tumor specimens of LC patients with and without the chronic respiratory condition
Epigenetic events | LC patients | |
|---|---|---|
Non-COPD | COPD | |
Lung tumors | ||
MicroRNAs | ||
miR-21, miR-200b, miR-210, miR-let7c | ↓ | ↑ |
miR-126, miR451, miR30a-30p, miR-155, miR-let7a | = | = |
Histone modifications | ||
HDAC2, Sirtuin-1 | = | = |
DNA methylation | ↓ | ↑ |