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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Bronchial biopsy specimen as a surrogate for DNA methylation analysis in inoperable lung cancer

Fig. 3

Evaluation of prediction performance of models. The prediction performance of the proposed model using the 10 CpGs was tested in 897 TCGA primary lung tissues (a, b) and in 136 bronchial washing samples (c, d). a, c The area under curve (AUC) of the receiver operating characteristic (ROC) in prediction of lung cancer using three models was 0.981–0.993 for 897 TCGA primary lung tissues and 0.720–0.786 for 136 bronchial washings. ROC curve was produced using MedCalc software. b, d The methylation levels of 10 CpGs selected in this study were compared between the 821 TCGA primary lung tumor tissues and 76 normal tissues (b) and between 76 lung cancer patients and 60 controls (d). All CpGs in the TCGA data were found to be highly methylated compared to the matched normal tissues (P < 0.0001; Wilcoxon rank-sum test). Although most CpGs in the bronchial washing samples did show a statistically significant difference in the methylation levels between 76 lung cancer patients and 60 controls, the difference was small compared to that in the TCGA data. The X- and Y-axes indicate CpG numbers and β-values from 450K array, respectively

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