Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes

Ntoumou, E.; Tzetis, M.; Braoudaki, M.; Lambrou, G.; Poulou, M.; Malizos, K.; Stefanou, N.; Anastasopoulou, L.; Tsezou, A.

doi:10.1186/s13148-017-0428-1

Table 2 Summary of 77 miRNAs that were found significant in ROC analysis in common annotated pathways

From: Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes

KEGG pathway	p value	#genes	#miRNAs
Proteoglycans in cancer	3.10E-11	156	64
Morphine addiction	1.07E-05	68	54
Circadian entrainment	1.07E-05	78	55
Adherens junction	3.37E-05	62	57
Phosphatidylinositol signaling system	6.91E-05	61	55
Axon guidance	6.91E-05	100	56
Glutamatergic synapse	6.91E-05	92	56
Thyroid hormone signaling pathway	0.000101627	90	62
Ras signaling pathway	0.000108175	167	66
Fatty acid biosynthesis	0.000111286	9	17
Retrograde endocannabinoid signaling	0.000113352	78	52
Rap1 signaling pathway	0.000113352	157	64
Dopaminergic synapse	0.000186561	101	57
Pathways in cancer	0.000227243	284	69
Hippo signaling pathway	0.000362414	111	62
N-Glycan biosynthesis	0.000416091	35	41
Inflammatory mediator regulation of TRP channels	0.000430502	74	48
GABAergic synapse	0.000725271	68	58
Long-term depression	0.001178836	48	46
Serotonergic synapse	0.001245646	81	51
TGF-beta signaling pathway	0.001498476	58	54
Pancreatic cancer	0.001536223	53	49
FoxO signaling pathway	0.001905724	98	59
ErbB signaling pathway	0.002223208	66	51
MAPK signaling pathway	0.002252012	183	66
Signaling pathways regulating pluripotency of stem cells	0.002265893	102	61
Wnt signaling pathway	0.002265893	104	63
Melanoma	0.002526033	56	49
Long-term potentiation	0.002526033	54	52
Nicotine addiction	0.004752071	29	43
Prion diseases	0.006877062	20	36
Circadian rhythm	0.006877062	26	41
PI3K-Akt signaling pathway	0.006877062	235	70
Prostate cancer	0.006944825	67	57
Neurotrophin signaling pathway	0.008178726	88	58
Oxytocin signaling pathway	0.008178726	111	62
mTOR signaling pathway	0.00860707	48	54
Endocrine and other factor-regulated calcium reabsorption	0.009616617	34	47
Renal cell carcinoma	0.009616617	52	47
Platelet activation	0.010946918	94	55
Adrenergic signaling in cardiomyocytes	0.010946918	102	60
Endocytosis	0.010946918	144	63
Non-small cell lung cancer	0.011911365	43	47
Cholinergic synapse	0.012031519	79	56
Glioma	0.012204133	47	48
cGMP-PKG signaling pathway	0.01268481	117	67
Endometrial cancer	0.01424854	40	54
Estrogen signaling pathway	0.01424854	70	55
Choline metabolism in cancer	0.01424854	73	62
Chronic myeloid leukemia	0.01491545	54	52
Calcium signaling pathway	0.01491545	126	59
GnRH signaling pathway	0.015627113	68	51
Gap junction	0.015668053	62	51
Amphetamine addiction	0.016450563	49	52
T cell receptor signaling pathway	0.018715138	76	52
Glycosaminoglycan biosynthesis-heparan sulfate/heparin	0.021909011	18	29
Dorso-ventral axis formation	0.021911194	23	40
ECM-receptor interaction	0.02302011	59	49
Focal adhesion	0.023875829	143	62
Regulation of actin cytoskeleton	0.027660198	149	66
Sphingolipid signaling pathway	0.035172679	80	57
Small cell lung cancer	0.046657913	62	45
Cocaine addiction	0.046657913	36	49
Ubiquitin-mediated proteolysis	0.046657913	98	61

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ISSN: 1868-7083

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