Table 3 Overviw of results from EWAS analyses for intra-pair difference in level of lung function at follow-up (p value < 10−5)
From: Lung function discordance in monozygotic twins and associated differences in blood DNA methylation
Lung function measure | Probe | Estimate | p value | Chromosome | Bp (hg19) | Proximal gene | CGI feature | Methylationa of “inferior” twin |
|---|---|---|---|---|---|---|---|---|
Log-ΔzFEV1IP | cg04261072 | − 0.054 | 4.33E−06 | 13 | 79,977,499 | RBM26 | Body-shelf | Hyper |
cg10196163 | − 0.062 | 7.62E−06 | 14 | 10,556,0628 | NA | IGR-shore | Hyper | |
cg12552820 | − 0.033 | 2.69E−06 | 1 | 2,231,925 | SKI | Body-shore | Hyper | |
cg13971574 | − 0.037 | 9.65E−06 | 2 | 39,102,874 | MORN2 | TSS1500-island | Hyper | |
cg18582260 | − 0.079 | 3.99E−06 | 13 | 25,085,301 | PARP4 | 5′UTR-shore | Hyper | |
cg20552903 | − 0.038 | 5.81E−06 | 6 | 33,289,678 | DAXX | Body-shore | Hyper | |
cg23759053 | − 0.136 | 5.99E−06 | 7 | 34,173,999 | BMPER | Body-open sea | Hyper | |
cg23840275 | − 0.045 | 2.62E−06 | 13 | 20,969,493 | NA | IGR-shore | Hyper | |
cg27180671 | − 0.050 | 7.51E−06 | 17 | 65,527,566 | PITPNC1 | Body-open sea | Hyper | |
Log-ΔzFVCIP | cg00008488 | − 0.0935 | 8.23E−06 | 5 | 175,199,915 | NA | IGR-shore | Hyper |
cg00306721 | − 0.0797 | 9.54E−06 | 11 | 62,477,480 | BSCL2 | TSS1500-island | Hyper | |
cg01028379 | 0.0617 | 2.84E−06 | 7 | 4,798,471 | FOXK1 | Body-shore | Hypo | |
cg02071292 | − 0.2366 | 7.14E−08 FDR | 12 | 75,785,097 | GLIPR1L2 | 1stExon-island | Hyper | |
cg07311024 | − 0.1553 | 1.96E−06 | 12 | 75,785,089 | GLIPR1L2 | 1stExon-island | Hyper | |
cg15909232 | − 0.1167 | 5.08E−06 | 7 | 156,235,420 | NA | IGR-open sea | Hyper | |
cg15942481 | − 0.1366 | 8.77E−06 | 12 | 75,785,230 | GLIPR1L2 | Body-island | Hyper | |
cg17154159 | 0.0832 | 6.02E−06 | 6 | 160,401,562 | IGF2R | Body-open sea | Hypo | |
cg22089890 | − 0.0391 | 4.20E−06 | 17 | 48,708,077 | NA | IGR – shelf | Hyper | |
cg25249300 | − 0.0660 | 1.36E−07 | 2 | 54,483,341 | TSPYL6 | 1stExon – island | Hyper | |
ΔzFEV1/FVCIP | cg00347643 | 0.1747 | 7.88E−06 | 7 | 75,957,202 | YWHAG | 3′UTR-shore | Hypo |
cg00995220 | 0.1333 | 2.13E−07 | 6 | 56,259,582 | NA | IGR-open sea | Hypo | |
cg04697953 | 0.0849 | 4.43E−06 | 2 | 179,299,404 | PRKRA | Body-open sea | Hypo | |
cg06244016 | 0.1917 | 2.17E−06 | 6 | 151,186,511 | MTHFD1L | TSS200-shore | Hypo | |
cg07219303 | 0.1575 | 3.92E−06 | 4 | 100,140,905 | ADH6 | TSS1500-open sea | Hypo | |
cg11980944 | 0.0863 | 8.55E−06 | 1 | 205,399,731 | NA | IGR-open sea | Hypo | |
cg13107302 | 0.0995 | 5.69E−06 | 17 | 75,237,970 | NA | IGR-open sea | Hypo | |
cg13912599 | 0.1229 | 2.66E−06 | 1 | 150,959,380 | ANXA9 | Body-open sea | Hypo | |
cg18221862 | − 0.1038 | 4.81E−06 | 2 | 193,059,230 | TMEFF2 | 1stExon-island | Hyper | |
cg18537205 | − 0.1205 | 9.86E−06 | 10 | 114,575,091 | VTI1A | Body-open sea | Hyper | |
cg19529957 | 0.1367 | 5.50E−06 | 7 | 4,198,590 | SDK1 | Body-open sea | Hypo |