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Table 3 Association of aberrant DNA methylation and clinical outcome in OPSCC patients

From: Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors

Gene Hyper-/hypomethylation Cohort Clinical outcome References
MGMT Hyper 88 OPSCC Poorer PFS and OS [45]
ALDH3A1 Hyper 76 HNSCC, including 15 OPSCC Decreased OS [172]
TAP1 Hyper
SMG1 Hypo 40 OPSCC Improved OS in HPV-positive OPSCC [153]
ALDH1A2 Hypo 170 OPSCC (3 independent cohorts) Improved clinical outcome in HPV-positive OPSCC [154]
GATA4 Hyper
GRIA4 Hyper
IRX4 Hyper
OSR2 Hypo
DAPK1 Hyper 70 HNSCC, including 9 OPSCC Lymph node metastasis [173]
MGMT Hyper
WIF1 Hyper 43 HNSCC, including 19 OPSCC Decreased OS [54]
GALR1/2 Hyper 202 HNSCC, including 58 OPSCC Poor survival with the highest association in HPV-negative OPSCC [174]
LINE-1 Hypo 110 OPSCC (2 independent cohorts) Increased risk of early relapse in HPV-negative OPSCC [60]
  1. ALDH aldehyde dehydrogenase, DAPK death-associated protein kinase, GALR galanin receptor, GATA GATA binding protein, GRIA glutamate receptor, IRX iroquois homeobox, LINE long interspersed nuclear element, MGMT O-6-methylguanine-DNA methyltransferases, OSR odd-skipped-related, SMG nonsense mediated mRNA decay associated PI3K-related kinase, TAP transporter associated with antigen processing, WIFI WNT inhibitory factor