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Table 3 Association of aberrant DNA methylation and clinical outcome in OPSCC patients

From: Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors

Gene

Hyper-/hypomethylation

Cohort

Clinical outcome

References

MGMT

Hyper

88 OPSCC

Poorer PFS and OS

[45]

ALDH3A1

Hyper

76 HNSCC, including 15 OPSCC

Decreased OS

[172]

TAP1

Hyper

SMG1

Hypo

40 OPSCC

Improved OS in HPV-positive OPSCC

[153]

ALDH1A2

Hypo

170 OPSCC (3 independent cohorts)

Improved clinical outcome in HPV-positive OPSCC

[154]

GATA4

Hyper

GRIA4

Hyper

IRX4

Hyper

OSR2

Hypo

DAPK1

Hyper

70 HNSCC, including 9 OPSCC

Lymph node metastasis

[173]

MGMT

Hyper

WIF1

Hyper

43 HNSCC, including 19 OPSCC

Decreased OS

[54]

GALR1/2

Hyper

202 HNSCC, including 58 OPSCC

Poor survival with the highest association in HPV-negative OPSCC

[174]

LINE-1

Hypo

110 OPSCC (2 independent cohorts)

Increased risk of early relapse in HPV-negative OPSCC

[60]

  1. ALDH aldehyde dehydrogenase, DAPK death-associated protein kinase, GALR galanin receptor, GATA GATA binding protein, GRIA glutamate receptor, IRX iroquois homeobox, LINE long interspersed nuclear element, MGMT O-6-methylguanine-DNA methyltransferases, OSR odd-skipped-related, SMG nonsense mediated mRNA decay associated PI3K-related kinase, TAP transporter associated with antigen processing, WIFI WNT inhibitory factor