Skip to main content

Table 1 Genes hypermethylated in OPSCC

From: Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors

Pathway

Gene

Name

Hypermethylated in

Region analyzed

Reference

Apoptosis

DAPK

Death-associated protein kinase 1

HPV-negative/positive

Promoter region

[39]

RASSF1

Ras association domain-containing protein 1

HPV-negative

− 244 from TSSa

[50]

Promoter region

[45, 51]

STAT5

Signal transducer and activator of transcription 5

HPV-negative

+ 42 from TSS

[50]

Cell cycle

CCNA1

Cyclin A1

HPV-positive

Promoter region

[51]

+ 7 from TSS

[50]

CDKN2A

Cyclin-dependent kinase inhibitor-2A

HPV-negative

Promoter region

[43,44,45, 51]

HPV-positive

Three loci within the CpG island of CDKN2A gene

[165]

 

CHFRb

Checkpoint with forkhead and ring finger domains

HPV-negative

Promoter region

[39]

 

TP73

Tumor protein p73

HPV-negative/positive

Promoter region

[39]

Cell fate determination

APC

Adenomatous polyposis coli

HPV-negative/positive

Promoter region

[39]

DNA repair

MGMT

O6-methylguanine-DNA methyltransferases

HPV-negative

− 272 from TSS

[50, 51]

Protein glycosylation

TUSC3

Tumor suppressor candidate 3

HPV-positive

+ 29 from TSS

[50]

Inflammation

JAK3

Janus kinase 3

HPV-positive

+ 64 from TSS

[50]

Invasion and metastasis

CADM1

Cell Adhesion Molecule 1

HPV-positive

Promoter region

[39]

CDH11

Cadherin 11

HPV-positive

− 354 from TSS

[50]

CDH13a

Cadherin 13

HPV-negative/positive

Promoter region

[39]

IGSF4

Immunoglobulin superfamily member 4

HPV-positive

Promoter region

[166]

SPDEF

SAM pointed domain-containing Ets transcription factor

HPV-negative

+ 116 from TSS

[50]

TIMP3

TIMP metallopeptidase inhibitor 3

HPV-positive

Promoter region

[39, 51]

SYBL1

Synaptobrevin-like 1

HPV-positive

− 349 from TSS

[50]

Signaling

ESR1

Estrogen receptor 2

HPV-negative/positive

Promoter region

[39]

ESR2

Estrogen receptor 2

HPV-negative

+ 66 from TSS

[50]

GALR1

Galanin receptor type 1/2

HPV-positive

Two loci within the CpG island of the GALR1 gene

[165]

GRB7

Growth factor receptor-bound protein 7

HPV-positive

− 160 from TSS

[50]

RARβa

Retinoic acid receptor β

HPV-negative/positive

Promoter region

[39]

Transcription

RUNX1T1

RUNX1 translocation partner 1

HPV-positive

+ 145 from TSS

[50]

TCF21

Transcription factor 21

HPV-positive

Promoter region

[167]

WNT signaling

SFRP1

Soluble frizzled receptor protein 1

Drinkers

Promoter region

[56]

SFRP4

Soluble frizzled receptor protein 4

HPV-positive

Promoter region

[56]

 

WIF1

WNT inhibitory factor 1

NA

Promoter region

[54]

  1. NA not applicable
  2. a TSS transcription start site
  3. bHypermethylation of these genes is associated with development of radioresistance in other tumor types