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Table 4 Association between DNA methylation levels at multiple CpG sites and gene polymorphisms in AXL in the primary study population (N = 207)

From: Epigenetic regulation of AXL and risk of childhood asthma symptoms

  

Average of near-TSS CpG sitesa

Average of gene-body CpG sitesb

Average of all 12 CpG sitesc

RS Number

Location

β

p

Adjusted p

β

p

Adjusted p

β

p

Adjusted p

rs2301235

41724671

0.60

0.14

0.29

0.09

0.64

0.79

0.35

0.11

0.26

rs2569692

41724687

1.55

2.9E−04

0.01

0.24

0.24

0.44

0.84

2.1E−04

0.01

rs28364580

41724885

1.16

0.005

0.05

0.34

0.07

0.22

0.67

0.002

0.03

rs1709122

41725754

1.21

4.2E−04

0.01

0.05

0.76

0.87

0.59

0.001

0.03

rs4803446

41726167

0.66

0.09

0.25

0.22

0.23

0.44

0.41

0.05

0.19

rs2271546

41727197

0.87

0.12

0.28

0.46

0.08

0.24

0.63

0.03

0.16

rs186235601

41728703

1.34

0.05

0.22

0.52

0.11

0.26

0.89

0.02

0.10

rs10409940

41728765

0.78

0.03

0.16

− 0.06

0.73

0.86

0.33

0.09

0.25

rs11083613

41729505

0.03

0.93

0.95

− 0.33

0.06

0.22

− 0.18

0.38

0.56

rs4803447

41731175

1.75

0.009

0.08

0.52

0.10

0.25

1.01

0.004

0.05

rs59423102

41731749

− 0.13

0.81

0.89

0.22

0.38

0.56

0.07

0.81

0.89

rs12462203

41732423

0.18

0.59

0.75

− 0.05

0.74

0.87

− 0.02

0.91

0.95

rs12984621

41732727

− 0.15

0.68

0.82

− 0.14

0.41

0.60

− 0.23

0.25

0.44

rs4802112

41734490

0.89

0.02

0.11

0.04

0.84

0.92

0.34

0.09

0.25

rs4803449

41734666

1.02

0.005

0.05

0.17

0.31

0.50

0.47

0.01

0.10

rs76249126

41737410

− 1.22

0.06

0.22

− 0.28

0.36

0.56

− 0.71

0.04

0.18

rs75955910

41737414

− 0.65

0.32

0.50

− 0.52

0.08

0.24

− 0.54

0.11

0.26

rs7246896

41738212

0.11

0.86

0.92

0.22

0.42

0.60

0.18

0.57

0.74

rs77287588

41739574

− 0.48

0.29

0.49

− 0.22

0.29

0.49

− 0.27

0.27

0.46

rs4802114

41741278

0.36

0.32

0.50

0.07

0.66

0.81

0.14

0.47

0.64

rs4637024

41743454

− 0.76

0.13

0.29

0.02

0.95

0.96

− 0.36

0.17

0.34

rs3786555

41748153

0.70

0.10

0.25

− 0.23

0.24

0.44

0.13

0.55

0.72

rs2304234

41748753

0.51

0.17

0.34

0.00

0.99

0.99

0.14

0.48

0.64

rs55841050

41750550

1.43

0.04

0.19

0.80

0.01

0.10

0.94

0.01

0.10

rs12983027

41753634

0.79

0.07

0.22

− 0.18

0.36

0.56

0.18

0.43

0.61

rs12978323

41756038

0.89

0.03

0.15

0.09

0.63

0.79

0.33

0.13

0.28

rs116056574

41759637

0.10

0.77

0.88

0.12

0.45

0.63

0.02

0.92

0.95

rs35546772

41764758

1.12

0.07

0.22

0.05

0.86

0.92

0.43

0.18

0.34

  1. SNP data was only available for a subset of subjects. SNPs were modeled as ordinal variables (0 = major allele, 1 = heterozygote, and 2 = minor allele), and models were adjusted for child’s sex, admixture, and gestational age. Beta values are showing the percent change in methylation per one unit increase in SNP. Tagging SNPs were defined with a pair tag r 2 > 0.8 in Haploview with all CHS samples (N = 3845). FDR was used to adjust for all tests performed at the 3 methylation averages (28 × 3 tests). Significant FDR-adjusted p values (< 0.05) are marked in italics
  2. TSS transcription start site
  3. aAverage of cg10564498, cg03247049, cg12722469, cg02372201, cg19848291, and cg14892768
  4. bAverage of cg27579501, cg00360107, cg19270050, cg24901063, and cg26521562
  5. cAverage of all 12 CpG sites