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Table 4 Association between DNA methylation levels at multiple CpG sites and gene polymorphisms in AXL in the primary study population (N = 207)

From: Epigenetic regulation of AXL and risk of childhood asthma symptoms

   Average of near-TSS CpG sitesa Average of gene-body CpG sitesb Average of all 12 CpG sitesc
RS Number Location β p Adjusted p β p Adjusted p β p Adjusted p
rs2301235 41724671 0.60 0.14 0.29 0.09 0.64 0.79 0.35 0.11 0.26
rs2569692 41724687 1.55 2.9E−04 0.01 0.24 0.24 0.44 0.84 2.1E−04 0.01
rs28364580 41724885 1.16 0.005 0.05 0.34 0.07 0.22 0.67 0.002 0.03
rs1709122 41725754 1.21 4.2E−04 0.01 0.05 0.76 0.87 0.59 0.001 0.03
rs4803446 41726167 0.66 0.09 0.25 0.22 0.23 0.44 0.41 0.05 0.19
rs2271546 41727197 0.87 0.12 0.28 0.46 0.08 0.24 0.63 0.03 0.16
rs186235601 41728703 1.34 0.05 0.22 0.52 0.11 0.26 0.89 0.02 0.10
rs10409940 41728765 0.78 0.03 0.16 − 0.06 0.73 0.86 0.33 0.09 0.25
rs11083613 41729505 0.03 0.93 0.95 − 0.33 0.06 0.22 − 0.18 0.38 0.56
rs4803447 41731175 1.75 0.009 0.08 0.52 0.10 0.25 1.01 0.004 0.05
rs59423102 41731749 − 0.13 0.81 0.89 0.22 0.38 0.56 0.07 0.81 0.89
rs12462203 41732423 0.18 0.59 0.75 − 0.05 0.74 0.87 − 0.02 0.91 0.95
rs12984621 41732727 − 0.15 0.68 0.82 − 0.14 0.41 0.60 − 0.23 0.25 0.44
rs4802112 41734490 0.89 0.02 0.11 0.04 0.84 0.92 0.34 0.09 0.25
rs4803449 41734666 1.02 0.005 0.05 0.17 0.31 0.50 0.47 0.01 0.10
rs76249126 41737410 − 1.22 0.06 0.22 − 0.28 0.36 0.56 − 0.71 0.04 0.18
rs75955910 41737414 − 0.65 0.32 0.50 − 0.52 0.08 0.24 − 0.54 0.11 0.26
rs7246896 41738212 0.11 0.86 0.92 0.22 0.42 0.60 0.18 0.57 0.74
rs77287588 41739574 − 0.48 0.29 0.49 − 0.22 0.29 0.49 − 0.27 0.27 0.46
rs4802114 41741278 0.36 0.32 0.50 0.07 0.66 0.81 0.14 0.47 0.64
rs4637024 41743454 − 0.76 0.13 0.29 0.02 0.95 0.96 − 0.36 0.17 0.34
rs3786555 41748153 0.70 0.10 0.25 − 0.23 0.24 0.44 0.13 0.55 0.72
rs2304234 41748753 0.51 0.17 0.34 0.00 0.99 0.99 0.14 0.48 0.64
rs55841050 41750550 1.43 0.04 0.19 0.80 0.01 0.10 0.94 0.01 0.10
rs12983027 41753634 0.79 0.07 0.22 − 0.18 0.36 0.56 0.18 0.43 0.61
rs12978323 41756038 0.89 0.03 0.15 0.09 0.63 0.79 0.33 0.13 0.28
rs116056574 41759637 0.10 0.77 0.88 0.12 0.45 0.63 0.02 0.92 0.95
rs35546772 41764758 1.12 0.07 0.22 0.05 0.86 0.92 0.43 0.18 0.34
  1. SNP data was only available for a subset of subjects. SNPs were modeled as ordinal variables (0 = major allele, 1 = heterozygote, and 2 = minor allele), and models were adjusted for child’s sex, admixture, and gestational age. Beta values are showing the percent change in methylation per one unit increase in SNP. Tagging SNPs were defined with a pair tag r 2 > 0.8 in Haploview with all CHS samples (N = 3845). FDR was used to adjust for all tests performed at the 3 methylation averages (28 × 3 tests). Significant FDR-adjusted p values (< 0.05) are marked in italics
  2. TSS transcription start site
  3. aAverage of cg10564498, cg03247049, cg12722469, cg02372201, cg19848291, and cg14892768
  4. bAverage of cg27579501, cg00360107, cg19270050, cg24901063, and cg26521562
  5. cAverage of all 12 CpG sites