Table 4 Univariate and multivariate analysis of ZNF331 methylation status with disease-free survival (DFS) and overall survival (OS) in colorectal cancer patients
Clinical parameter | DFS | OS | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
Age (< 60 vs. ≥ 60 years) | 1.099 (0.604–1.999) | 0.757 | 1.132 (0.622–2.058) | 0.685 | ||||
Gender (male vs female) | 1.129 (0.603–2.114) | 0.704 | 1.080 (0.577–2.023) | 0.810 | ||||
ZNF331 (methylation vs. unmethylation) | 0.273 (0.115–0.648) | 0.003** | 0.279 (0.117–0.664) | 0.004** | 0.261 (0.110–0.620) | 0.002** | 0.271 (0.114–0.646) | 0.003** |
Tumor differentiation (moderate or well vs. poor) | 0.467 (0.254–0.857) | 0.014* | 0.727 (0.392–1.347) | 0.311 | 0.471 (0.257–0.863) | 0.015* | 0.736 (0.397–01.365) | 0.331 |
TNM stage (I–II vs. III–IV) | 0.139 (0.062–0.312) | 0.000*** | 0.151 (0.066–0.345) | 0.000*** | 0.147 (0.065–0.332) | 0.000*** | 0.164 (0.072–0.375) | 0.000*** |
Tumor size (< 5 vs. ≥ 5 cm) | 0.798 (0.438–1.453) | 0.461 | 0.812 (0.446–1.478) | 0.495 | ||||
Tumor location (left colon vs. right colon) | 1.577 (0.810–3.072) | 0.180 | 1.579 (0.811–3.075) | 0.179 | ||||
KRAS mutation (wide type vs. mutation) | 0.797 (0.418–1.520) | 0.491 | 0.810 (0.425–1.545) | 0.522 | ||||
BRAF 600E mutation (wide type vs. mutation) | 0.488 (0.118–2.025) | 0.323 | 0.396 (0.095–1.642) | 0.202 | ||||
CIMP (high vs. low) | 1.155 (0.412–3.242) | 0.784 | 1.138 (0.405–3.192) | 0.806 | ||||