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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure

Fig. 5

Effects of PAE on the fractional synthesis of doubly modified H2A in frontal cortex and hypothalamus of rat brain. We measured the incorporation of 2H in unmodified H2A (H2Aun) and H2AK120meK126ac (vTIAQGGVLPNIQAVLLPkkTESHHk) in the frontal cortex (a) and the hypothalamus (b) of 6-day-old rat pups following a 5-day alcohol feeding and administration of 2H2O. Histone Fractional Synthesis Rate (FSR) was calculated and data are shown as mean ± SE, n = 4 per group, **p < 0.01, AF vs PF

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