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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

Fig. 6

A proposed model for Hippo pathway regulation by KIBRA promoter methylation. a SP1 binds to conserved DNA recognition elements within KIBRA promoter regions leading to enhanced KIBRA expression and Hippo pathway activation. b SP1 recruitment to KIBRA promoter regions may be prevented by CpG methylation leading to reduced KIBRA expression and impaired Hippo pathway activation. Alterations of the Hippo pathway due to KIBRA promoter methylation may be associated with onset or progression of renal cell carcinoma

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Clinical Epigenetics

ISSN: 1868-7083

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