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Table 2 Associations of estimated cell counts at 7.5 and 16.5 years with current asthma status at 7.5 and 16.5 years respectively

From: Epigenome-wide association study of asthma and wheeze in childhood and adolescence

  Current asthma at 7.5 years Current asthma at 16.5 years
  Change in proportiona [95%CI] P value Change in proportiona [95%CI] P value
Monocytes − 0.002 [− 0.005, 0.004] 0.695 − 0.003 [− 0.007, 0.004] 0.534
CD8T 0.002 [− 0.008, 0.009] 0.777 − 0.004 [− 0.013, 0.007] 0.496
CD4T 0.009 [− 0.002, 0.018] 0.069 0.009 [0, 0.018] 0.055
B cells 0.011 [0.005, 0.018] < 0.001 0.005 [− 0.003,0.01] 0.173
NK cells − 0.004 [− 0.008, 0.002] 0.159 − 0.004 [− 0.01,0.004] 0.306
Granulocytesb − 0.016 [− 0.032, 0.001] 0.065 − 0.005 [− 0.023, 0.014] 0.618
Neutrophils − 0.042 [− 0.06, − 0.022] < 0.001 − 0.009 [− 0.029, 0.011] 0.382
Eosinophils 0.026 [0.018, 0.033] < 0.001 0.005 [0.002, 0.008] 0.008
  1. aChange in proportion for individuals with asthma
  2. bGranulocytes calculated from the summed proportions of eosinophils and neutrophils