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Table 2 Associations of estimated cell counts at 7.5 and 16.5 years with current asthma status at 7.5 and 16.5 years respectively

From: Epigenome-wide association study of asthma and wheeze in childhood and adolescence

 

Current asthma at 7.5 years

Current asthma at 16.5 years

 

Change in proportiona [95%CI]

P value

Change in proportiona [95%CI]

P value

Monocytes

− 0.002 [− 0.005, 0.004]

0.695

− 0.003 [− 0.007, 0.004]

0.534

CD8T

0.002 [− 0.008, 0.009]

0.777

− 0.004 [− 0.013, 0.007]

0.496

CD4T

0.009 [− 0.002, 0.018]

0.069

0.009 [0, 0.018]

0.055

B cells

0.011 [0.005, 0.018]

< 0.001

0.005 [− 0.003,0.01]

0.173

NK cells

− 0.004 [− 0.008, 0.002]

0.159

− 0.004 [− 0.01,0.004]

0.306

Granulocytesb

− 0.016 [− 0.032, 0.001]

0.065

− 0.005 [− 0.023, 0.014]

0.618

Neutrophils

− 0.042 [− 0.06, − 0.022]

< 0.001

− 0.009 [− 0.029, 0.011]

0.382

Eosinophils

0.026 [0.018, 0.033]

< 0.001

0.005 [0.002, 0.008]

0.008

  1. aChange in proportion for individuals with asthma
  2. bGranulocytes calculated from the summed proportions of eosinophils and neutrophils