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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma

Fig. 2

The expression and methylation status of HOXD10 in primary HCC. a Representative MSP results of HOXD10 in normal liver tissue samples and primary HCC samples. N: normal liver tissue samples; HCC: primary HCC samples. b The 3-year overall survival curves for patients in the methylated and unmethylated groups (P < 0.05). c Representative IHC results show HOXD10 expression in HCC tissue and adjacent tissue samples (top: ×200; bottom: ×400). d The expression of HOXD10 and DNA methylation status is shown as a bar diagram. Reduced expression of HOXD10 was significantly associated with promoter region hypermethylation. *P < 0.05, r = 0.33. e HOXD10 expression scores are shown as box plots; horizontal lines represent the median score; the bottom and top of the boxes represent the 25th and 75th percentiles, respectively; vertical bars represent the range of data. Expression of HOXD10 was significantly different between adjacent tissue and HCC tissue in 40-matched HCC samples. ***P < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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