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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Mosaic genome-wide maternal isodiploidy: an extreme form of imprinting disorder presenting as prenatal diagnostic challenge

Fig. 3

DNA methylation analysis in uncultured amniotic fluid cells. Results of methylation-specific MLPA analysis in uncultured amniotic fluid cells are depicted. Controls consist of three normal samples from amniotic fluid. Upper panel: copy number analysis. Blue bars in the upper histogram: relative control peak area (RPA-C). Green bars in the upper histogram: relative patient peak area (RPA-P). The lower histogram shows the ratio-relative peak area (RPA-P/RPA-C × 100) as blue bars. Lower panel: DNA methylation analysis. Blue bars in the upper histogram: relative control peak area (RPA-C) in % methylation. Green bars in the upper histogram: relative patient peak area (RPA-P) in % methylation. The lower histogram shows the ratio relative peak area (RPA-P/RPA-C × 100): blue bars indicate paternally methylated loci and pink bars indicate maternally methylated loci

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