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Table 4 Pearson correlations of cord blood GABBR1 DNA methylation (average and separate CpG units) with infant HPA axis cortisol measurements in response to routine vaccination at 2 and 4 months of age

From: Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

 

GABBR1 DNA methylation

Child HPA axis stress response

CpG_1.2

CpG_3

CpG_6

CpG_8

CpG_9.10

CpG_11

CpG_14.15

CpG_16

CpG_17

Average GABBR1

2 M (n = 20)

AUCi

Pearson R

0.372

− 0.476

0.029

− 0.452

0.109

0.062

0.375

0.238

0.218

− 0.152

p value

0.141

0.053

0.924

0.091

0.678

0.826

0.153

0.375

0.418

0.547

Initial response

Pearson R

0.141

− 0.47

0.092

− 0.270

0.120

− 0.004

0.448

0.125

0.172

− 0.098

p value

0.565

0.043

0.745

0.295

0.624

0.989

0.062

0.621

0.494

0.680

Recovery slope

Pearson R

0.141

− 0.283

0.063

− 0.162

0.118

− 0.103

0.342

− 0.012

0.083

− 0.086

p value

0.576

0.255

0.830

0.550

0.641

0.716

0.179

0.964

0.751

0.727

4 M (n = 67)

AUCi

Pearson R

0.260

0.239

0.241

0.200

0.084

0.096

0.080

0.186

0.082

0.168

p value

0.041

0.079

0.091

0.150

0.538

0.487

0.553

0.177

0.547

0.189

Initial response

Pearson R

0.392a

0.215

0.35

0.3

0.166

0.184

0.077

0.160

0.136

0.202

p value

0.001

0.102

0.009

0.023

0.210

0.166

0.556

0.230

0.301

0.100

Recovery slope

Pearson R

0.400a

0.219

0.38

0.35

0.209

0.27

0.130

0.192

0.182

0.225

p value

0.001

0.102

0.005

0.010

0.115

0.047

0.327

0.159

0.173

0.071

  1. aSignificant at the α level of 0.0019, corrected for 27 tests (3 cortisol variables and 9 CpG sites)