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Table 4 Pearson correlations of cord blood GABBR1 DNA methylation (average and separate CpG units) with infant HPA axis cortisol measurements in response to routine vaccination at 2 and 4 months of age

From: Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

  GABBR1 DNA methylation
Child HPA axis stress response CpG_1.2 CpG_3 CpG_6 CpG_8 CpG_9.10 CpG_11 CpG_14.15 CpG_16 CpG_17 Average GABBR1
2 M (n = 20) AUCi Pearson R 0.372 − 0.476 0.029 − 0.452 0.109 0.062 0.375 0.238 0.218 − 0.152
p value 0.141 0.053 0.924 0.091 0.678 0.826 0.153 0.375 0.418 0.547
Initial response Pearson R 0.141 − 0.47 0.092 − 0.270 0.120 − 0.004 0.448 0.125 0.172 − 0.098
p value 0.565 0.043 0.745 0.295 0.624 0.989 0.062 0.621 0.494 0.680
Recovery slope Pearson R 0.141 − 0.283 0.063 − 0.162 0.118 − 0.103 0.342 − 0.012 0.083 − 0.086
p value 0.576 0.255 0.830 0.550 0.641 0.716 0.179 0.964 0.751 0.727
4 M (n = 67) AUCi Pearson R 0.260 0.239 0.241 0.200 0.084 0.096 0.080 0.186 0.082 0.168
p value 0.041 0.079 0.091 0.150 0.538 0.487 0.553 0.177 0.547 0.189
Initial response Pearson R 0.392a 0.215 0.35 0.3 0.166 0.184 0.077 0.160 0.136 0.202
p value 0.001 0.102 0.009 0.023 0.210 0.166 0.556 0.230 0.301 0.100
Recovery slope Pearson R 0.400a 0.219 0.38 0.35 0.209 0.27 0.130 0.192 0.182 0.225
p value 0.001 0.102 0.005 0.010 0.115 0.047 0.327 0.159 0.173 0.071
  1. aSignificant at the α level of 0.0019, corrected for 27 tests (3 cortisol variables and 9 CpG sites)