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Table 2 LncRNA transcripts differentially expressed in stenotic aortic valves and experimentally modified aortic valve cells

From: Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy

LNCRNA name; symbol Expression in stenotic valves and aortic valve cells [reference]
Psoriasis associated non-protein coding RNA induced by stress; PRINS/ NCRNA00074
AFAP1 Antisense RNA 1; AFAP1-AS1/ MGC10981
CCND1 associated ncRNA
↑ AS [46]
MIR155 Host Gene; MIR155HG / BIC (B-cell receptor inducible)/ NCRNA00172
Long intergenic non-protein coding RNA 467; LINC00607/LOC646324
RUNX1 Intronic Transcript 1; RUNX1-IT1/ C21orf96
↑ AS [99]
Imprinted maternally expressed transcript (Non-Protein Coding); H19 / LINC00008 ↑ AS [99]
↓ HAVECsc (FO/VL; FO/FL; VO/VL) [77]
(NOTH1+/−) ECsa (only static significant) [67]
Long intergenic non-protein coding RNA 1094; LINC01094
Long intergenic non-protein coding RNA 475; LINC00475/ C9orf44
↑ TAVc vs. TAVn [182]
KLF3 antisense RNA 1; KLF3-AS1/ flj13197
PGM5 antisense RNA 1; PGM5-AS1 /FAM233A (family with sequence similarity 233, Member A)
IL10RB antisense RNA 1 (head to head); IL10RB-AS1 / IFNAR2-AS1 (IFNAR2 Antisense RNA 1)/LOC100288432
Long intergenic non-protein coding RNA 1094; LINC01094 /LOC100505702
Chromosome 8 Open Reading Frame 49; C8orf49/ G4DM (GATA4 downstream Membrane Protein)
Mir-99a-let-7c cluster host gene; MIR99AHG / LINC00478/ C21orf34
FLJ38717 /LOC401261- ncRNA
↑ AS vs. control [114]
↑ AS vs. fibro(sclerotic) group [114]
APCDD1L Antisense RNA 1 (head to head); APCDD1L-AS1
Long intergenic non-protein coding RNA 1013; LINC01013
↑ TAVc vs. TAVn ↑ BAVc vs. TAVn [182]
MIR4435–2 host gene; MIR4435-1HG/ MIR4435–2HG/LOC541471 ↑ AS [99] ↑ TAVc vs. TAVn ↑ BAVc vs. TAVn [182]
Long intergenic non-protein coding RNA 1279; LINC01279
Nuclear paraspeckle assembly transcript 1 (Non-Protein Coding); NEAT1/ LINC00084
↑ BAVc vs. TAVn [182]
Cytoskeleton regulator RNA; CYTOR/ LINC00152/C2orf59/NCRNA00152 ↑ BAVc vs. TAVn [182]
(NOTH1+/−) ECsa (only shear significant) [67]
Metastasis associated lung adenocarcinoma transcript 1 (Non-Protein Coding); MALAT 1/ LINC00047/NCRNA00047 ↑ AS [99]
↓ AS ↓ HAVICs [100]
TMEM161B antisense RNA 1; TMEM161B-AS1/AK082072 /linc-POLR3G-8
APOA1 antisense RNA; APOA1-AS1
PTENP1 antisense RNA; PTENP1-AS
SOX2 overlapping transcript; SOX2-OT/ DKFZp761J1324/NCRNA0004
↓ Calcified TAV [46]
Long intergenic non-protein coding RNA 1896; LINC01896 /LOC649504
Long intergenic non-protein coding RNA 1697; LINC01967 /LOC284825
HLA complex group 11 (non-protein coding; HCG11
↓AS [99]
Rhabdomyosarcoma 2 associated transcript (non-protein coding); RMST / LINC00054/NCRMS ↓ AS [99, 114]
HAND2 Antisense RNA 1 (Head to Head); HAND2-AS1/ NBLA00301 ↓ AS [99, 114]
↓ AS vs. fibro(sclerotic) group [114]
Prader Willi/Angelman region RNA 6; PWAR6/ LOC100506965 ↓ AS vs. fibro(sclerotic) group [114]
TRHDE antisense RNA 1; TRHDE-AS1 ↓ TAVc vs. TAVn ↓ BAVc vs. TAVn [182]
Long Intergenic Non-Protein Coding RNA 92; LINC00092 / NCRNA00092 ↓ TAVc vs. TAVn ↓ BAVc vs. TAVn [182]
↑ HAVICs1 [78]
Long intergenic non-protein coding RNA 894; LINC00894
Long intergenic non-protein coding RNA 1354; LINC01354
↓ BAVc vs. TAV [182]
OIP5 antisense RNA 1; OIP5-AS1/Cyrano/LOC729082 ↓ Calcified TAV [46]
↓ HAVICs1 [78]
Maternally Expressed 3 (Non-Protein Coding); MEG3 / LINC00023 ↓AS [114]
↓ HAVECsc (FO/VL) [77]
HLA Complex P5 (Non-Protein Coding); HCP5 ↑ HAVECsc (FO/VL; FO/FL) [77]
MIR503 host gene; MIR503HG/ H19X (H19 X-Linked Co-Expressed LncRNA)/ MIR503 Host Gene/ MGC16121
EPB41L4A Antisense RNA 1; EPB41L4A-AS1 / NCRNA00219/C5orf26/TIGA1
↑ HAVECsc (FO/VL; FO/FL; VO/VL) [77]
Long intergenic non-protein coding RNA 467; LINC00467/ C1orf97 ↑ HAVECsc (FO/VL; FO/FL; VO/VL) [77]
↓ HAVICs1 [78]
ASTN2 antisense RNA 1; ASTN2-AS1/ LOC100128505
LOC100133669 -ncRNA
LOC729970 /hCG2028352-like/ncRNA
IGFBP7 antisense RNA 1; IGFBP7-AS1/ LOC255130
Long intergenic non-protein coding RNA 294; LINC00294/ LOC283267
cancer susceptibility candidate 15 (non-protein coding); CASC15/ LINC00340/FLJ22536
Long intergenic non-protein coding RNA 2035; LINC02035/ LOC100129550
↑ HAVICs1 [78]
HHIP antisense RNA 1; HHIP-AS1/ LOC646576
FAM13A antisense RNA 1; FAM13A-AS1/ NCRNA00039
KDM4A antisense RNA 1; KDM4-AS1/ LOC100132774
Long intergenic non-protein coding RNA 938; LINC00938/ LOC400027
Long intergenic non-protein coding RNA 998; LINC00998 /LOC401397
Long intergenic non-protein coding RNA 623; LINC00623/ LOC728855
Long intergenic non-protein coding RNA 273; LINC00273/ LOC649159
↓ HAVICs1 [78]
Neighbor of BRCA1 Gene 2 (Non-Protein Coding); NBR2/ NCRNA00192 ↑ PAVECs* [177]
Long intergenic non-protein coding RNA 862; LINC00862/ C1orf98 HAVECsb [63]
  1. Legend: AS- aortic valve stenosis; BAVC- calcified stenotic bicuspid aortic valve; BAVr- bicuspid aortic valve with redundant leaflets and/or minimal calcification; HAVECs- human aortic valve endothelial cells; HAVICs- human aortic valve interstitial cells; FO-fibrosa, oscillatory shear stress; FL- fibrosa, laminar shear stress; (NOTH1+/−) ECs- hiPSC (human induced pluripotent stem cell)-derived endothelial cells generated from two patients with nonsense mutations in NOTCH1; PAVECs- porcine aortic valve interstitial cells; TAVc- calcified stenotic tricuspid aortic valve; TAVn -noncalcified tricuspid aortic valve, without stenosis; VL- ventricularis, laminar shear stress; VO- ventricularis, oscillatory shear stress. [46]- 9 tricuspid AS and 10 control nonmineralized aortic valves, male subjects; [184]- 5 tricuspid AS and 5 control nonmineralized aortic valves, male subjects; [92]- 10 BAVc, 9 TAVc and 8 control TAVn, male subjects; [101]- AS (5 TAVc/1BAVc), fibro(sclerotic) group (5 TAV/2 BAV), control (5 TAVn/1 BAVn), male subjects
  2. 1Genes altered > 1.2-fold with a p < 0.05 in the HOTAIR siRNA microarray data; aNOTCH1 haploinsufficiency, shear or static flow significant; baffected by flow and decreased NOTCH1; cshear-sensitive transcripts; *shear stress conditions modeling laminar flow. NOTE: Official gene symbols are presented in bold and italicized, aliases are in italics