Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy

Gošev, Igor; Zeljko, Martina; Đurić, Željko; Nikolić, Ivana; Gošev, Milorad; Ivčević, Sanja; Bešić, Dino; Legčević, Zoran; Paić, Frane

doi:10.1186/s13148-017-0406-7

Clinical Epigenetics

Table 2 LncRNA transcripts differentially expressed in stenotic aortic valves and experimentally modified aortic valve cells

From: Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy

LNCRNA name; symbol	Expression in stenotic valves and aortic valve cells [reference]
Psoriasis associated non-protein coding RNA induced by stress; *PRINS/* NCRNA00074 AFAP1 Antisense RNA 1; *AFAP1-AS1/* MGC10981 *CCND1 associated ncRNA*	↑ AS [46]
MIR155 Host Gene; *MIR155HG* / BIC (B-cell receptor inducible)/ NCRNA00172 Long intergenic non-protein coding RNA 467; *LINC00607/LOC646324* RUNX1 Intronic Transcript 1; *RUNX1-IT1/* C21orf96	↑ AS [99]
Imprinted maternally expressed transcript (Non-Protein Coding); *H19* / LINC00008	↑ AS [99] ↓ HAVECs^c (FO/VL; FO/FL; VO/VL) [77] (NOTH1+/−) ECs^a (only static significant) [67]
Long intergenic non-protein coding RNA 1094; *LINC01094* Long intergenic non-protein coding RNA 475; *LINC00475/* C9orf44	↑ TAVc vs. TAVn [182]
KLF3 antisense RNA 1; *KLF3-AS1/* flj13197 PGM5 antisense RNA 1; *PGM5-AS1* /FAM233A (family with sequence similarity 233, Member A) IL10RB antisense RNA 1 (head to head); *IL10RB-AS1* / IFNAR2-AS1 (IFNAR2 Antisense RNA 1)/LOC100288432 Long intergenic non-protein coding RNA 1094; *LINC01094* /LOC100505702 Chromosome 8 Open Reading Frame 49; *C8orf49/* G4DM (GATA4 downstream Membrane Protein) Mir-99a-let-7c cluster host gene; *MIR99AHG* / LINC00478/ C21orf34 *FLJ38717* /LOC401261- ncRNA	↑ AS vs. control [114] ↑ AS vs. fibro(sclerotic) group [114]
APCDD1L Antisense RNA 1 (head to head); *APCDD1L-AS1* Long intergenic non-protein coding RNA 1013; *LINC01013*	↑ TAVc vs. TAVn ↑ BAVc vs. TAVn [182]
MIR4435–2 host gene; *MIR4435-1HG/* MIR4435–2HG/LOC541471	↑ AS [99] ↑ TAVc vs. TAVn ↑ BAVc vs. TAVn [182]
Long intergenic non-protein coding RNA 1279; *LINC01279* Nuclear paraspeckle assembly transcript 1 (Non-Protein Coding); *NEAT1/* LINC00084	↑ BAVc vs. TAVn [182]
Cytoskeleton regulator RNA; *CYTOR/* LINC00152/C2orf59/NCRNA00152	↑ BAVc vs. TAVn [182] (NOTH1+/−) ECs^a (only shear significant) [67]
Metastasis associated lung adenocarcinoma transcript 1 (Non-Protein Coding); MALAT 1/ LINC00047/NCRNA00047	↑ AS [99] ↓ AS ↓ HAVICs [100]
TMEM161B antisense RNA 1; *TMEM161B-AS1/AK082072 /linc-POLR3G-8* APOA1 antisense RNA; *APOA1-AS1* PTENP1 antisense RNA; *PTENP1-AS* SOX2 overlapping transcript; *SOX2-OT/* DKFZp761J1324/NCRNA0004	↓ Calcified TAV [46]
Long intergenic non-protein coding RNA 1896; *LINC01896* /LOC649504 Long intergenic non-protein coding RNA 1697; *LINC01967* /LOC284825 HLA complex group 11 (non-protein coding; *HCG11*	↓AS [99]
Rhabdomyosarcoma 2 associated transcript (non-protein coding); *RMST* / LINC00054/NCRMS	↓ AS [99, 114]
HAND2 Antisense RNA 1 (Head to Head); *HAND2-AS1/* NBLA00301	↓ AS [99, 114] ↓ AS vs. fibro(sclerotic) group [114]
Prader Willi/Angelman region RNA 6; *PWAR6/* LOC100506965	↓ AS vs. fibro(sclerotic) group [114]
TRHDE antisense RNA 1; *TRHDE-AS1*	↓ TAVc vs. TAVn ↓ BAVc vs. TAVn [182]
Long Intergenic Non-Protein Coding RNA 92; *LINC00092* / NCRNA00092	↓ TAVc vs. TAVn ↓ BAVc vs. TAVn [182] ↑ HAVICs¹ [78]
Long intergenic non-protein coding RNA 894; *LINC00894* Long intergenic non-protein coding RNA 1354; *LINC01354*	↓ BAVc vs. TAV [182]
OIP5 antisense RNA 1; *OIP5-AS1*/Cyrano/LOC729082	↓ Calcified TAV [46] ↓ HAVICs¹ [78]
Maternally Expressed 3 (Non-Protein Coding); *MEG3* / LINC00023	↓AS [114] ↓ HAVECs^c (FO/VL) [77]
HLA Complex P5 (Non-Protein Coding); *HCP5*	↑ HAVECs^c (FO/VL; FO/FL) [77]
MIR503 host gene; *MIR503HG/* H19X (H19 X-Linked Co-Expressed LncRNA)/ MIR503 Host Gene/ MGC16121 EPB41L4A Antisense RNA 1; *EPB41L4A-AS1* / NCRNA00219/C5orf26/TIGA1	↑ HAVECs^c (FO/VL; FO/FL; VO/VL) [77]
Long intergenic non-protein coding RNA 467; *LINC00467/* C1orf97	↑ HAVECs^c (FO/VL; FO/FL; VO/VL) [77] ↓ HAVICs¹ [78]
ASTN2 antisense RNA 1; *ASTN2-AS1/* LOC100128505 *LOC100133669* -ncRNA *LOC729970* /hCG2028352-like/ncRNA IGFBP7 antisense RNA 1; *IGFBP7-AS1/* LOC255130 Long intergenic non-protein coding RNA 294; *LINC00294/* LOC283267 cancer susceptibility candidate 15 (non-protein coding); *CASC15/* LINC00340/FLJ22536 Long intergenic non-protein coding RNA 2035; *LINC02035/* LOC100129550	↑ HAVICs¹ [78]
HHIP antisense RNA 1; *HHIP-AS1/* LOC646576 FAM13A antisense RNA 1; *FAM13A-AS1/* NCRNA00039 KDM4A antisense RNA 1; *KDM4-AS1/* LOC100132774 Long intergenic non-protein coding RNA 938; *LINC00938/* LOC400027 Long intergenic non-protein coding RNA 998; *LINC00998* /LOC401397 Long intergenic non-protein coding RNA 623; *LINC00623/* LOC728855 Long intergenic non-protein coding RNA 273; *LINC00273/* LOC649159	↓ HAVICs¹ [78]
Neighbor of BRCA1 Gene 2 (Non-Protein Coding); *NBR2/* NCRNA00192	↑ PAVECs* [177]
Long intergenic non-protein coding RNA 862; *LINC00862/* C1orf98	HAVECs^b [63]

Legend: AS- aortic valve stenosis; BAVC- calcified stenotic bicuspid aortic valve; BAVr- bicuspid aortic valve with redundant leaflets and/or minimal calcification; HAVECs- human aortic valve endothelial cells; HAVICs- human aortic valve interstitial cells; FO-fibrosa, oscillatory shear stress; FL- fibrosa, laminar shear stress; (NOTH1+/−) ECs- hiPSC (human induced pluripotent stem cell)-derived endothelial cells generated from two patients with nonsense mutations in NOTCH1; PAVECs- porcine aortic valve interstitial cells; TAVc- calcified stenotic tricuspid aortic valve; TAVn -noncalcified tricuspid aortic valve, without stenosis; VL- ventricularis, laminar shear stress; VO- ventricularis, oscillatory shear stress. [46]- 9 tricuspid AS and 10 control nonmineralized aortic valves, male subjects; [184]- 5 tricuspid AS and 5 control nonmineralized aortic valves, male subjects; [92]- 10 BAVc, 9 TAVc and 8 control TAVn, male subjects; [101]- AS (5 TAVc/1BAVc), fibro(sclerotic) group (5 TAV/2 BAV), control (5 TAVn/1 BAVn), male subjects
¹Genes altered > 1.2-fold with a p < 0.05 in the HOTAIR siRNA microarray data; ^aNOTCH1 haploinsufficiency, shear or static flow significant; ^baffected by flow and decreased NOTCH1; ^cshear-sensitive transcripts; *shear stress conditions modeling laminar flow. NOTE: Official gene symbols are presented in bold and italicized, aliases are in italics

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ISSN: 1868-7083

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