Fig. 1

Major epigenetics mechanisams acting in mammalian cells. Presented are the four epigenetic mechanisams and their major impact on cellular gene regulation. Some writers (proteins that establish epigenetic marks) and riders (proteins that interpret epigenetic marks) are also illustrated. DNMT DNA methyl transferase, CBX3 Chromobox 3, CLOCK clock circadian regulator, DPF3A double PHD fingers 3a, 5hm 5 methyl cytosine, HAT1 histone acetyltransferase 1, HMT histone methyl transferase, ING2 inhibitor of growth family member 2, KMT2A lysine methyltransferase 2a, MeCP2 methyl CpG binding protein 2, MBD1 methyl-CpG-binding domain protein 1, MLL 1–5 family of lysine methyltransferases, MYSTs family of histone acetyltransferase, p300 histone acetyltransferase P300, PRMT1 protein arginine methyltransferase 1, p160 MYB binding protein 1a, SAM S-adenosyl methionine, SET1/ASH2 histone methyltransferase complex, SUV39H1 histone-lysine N-methyltransferase