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Table 3 Differentially methylated positions for WC and abdominal obesity (WC ≥ 88 cm for women and ≥ 102 cm for men)

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

     

WC

Abdominal obesity

CpG site

CHR

Position

Nearest genea

Featureb

Delta

β valuec

p valued

FDRd

Delta

β valuec

p valued

FDRd

cg07839457

16

57023022

NLRC5

TSS1500

0.0030

2.24E − 10

9.61E − 05

0.0340

6.86E − 05

8.17E − 01

cg00574958

11

68607622

CPT1A

5′ UTR

− 0.0007

1.00E − 08

1.55E − 03

− 0.0135

1.52E − 08

6.54E − 03

cg25954539

6

31323677

HLA-B

Body

0.0022

1.08E − 08

1.55E − 03

0.0316

5.78E − 05

7.75E − 01

cg08818207

6

32820355

TAP1

Body

0.0020

3.46E − 08

3.71E − 03

0.0303

5.14E − 05

7.75E − 01

cg04927537

17

76976091

LGALS3BP

TSS200

0.0013

6.19E − 08

5.08E − 03

0.0195

4.23E − 05

7.75E − 01

cg22107533

15

45028083

TRIM69

TSS1500

0.0015

7.76E − 08

5.08E − 03

0.0252

2.14E − 04

8.17E − 01

cg01309328

6

32811253

PSMB8

Body

0.0014

8.69E − 08

5.08E − 03

0.0202

6.26E − 06

6.45E − 01

cg23533285

6

31322348

HLA-B

Body

0.0015

9.47E − 08

5.08E − 03

0.0241

2.99E − 04

8.17E − 01

cg23570810

11

315102

IFITM1

Body

0.0018

1.12E − 07

5.35E − 03

0.0182

1.12E − 05

6.68E − 01

cg00218406

6

31431407

HCP5

3′ UTR

0.0022

1.66E − 07

7.12E − 03

0.0335

7.64E − 04

8.17E − 01

cg08099136

6

32811251

PSMB8

Body

0.0015

1.93E − 07

7.53E − 03

0.0180

3.23E − 04

8.17E − 01

cg11202345

17

76976057

LGALS3BP

1stExon

0.0011

2.15E − 07

7.70E − 03

0.0203

4.65E − 05

7.75E − 01

cg25178683

17

76976267

LGALS3BP

TSS1500

0.0011

3.50E − 07

1.16E − 02

0.0136

1.41E − 05

6.68E − 01

cg01971407

11

313624

IFITM1

TSS1500

0.0010

4.69E − 07

1.44E − 02

0.0079

5.71E − 05

7.75E − 01

cg25843003

6

31431312

HCP5

3′ UTR

0.0009

7.03E − 07

2.01E − 02

0.0142

8.12E − 05

8.17E − 01

cg22940798

6

32805554

TAP2

Body

0.0010

1.03E − 06

2.75E − 02

0.0187

5.19E − 04

8.17E − 01

cg20399616

12

25055967

BCAT1

Body

− 0.0012

1.20E − 06

2.97E − 02

− 0.0145

9.27E − 04

8.17E − 01

cg05439368

15

45028098

TRIM69

TSS1500

0.0015

1.25E − 06

2.97E − 02

0.0263

1.99E − 04

8.17E − 01

cg06538684

12

12511223

LOH12CR2

TSS1500

0.0011

1.62E − 06

3.53E − 02

0.0173

9.31E − 05

8.17E − 01

cg23235965

6

30459540

HLA-E

Body

0.0011

1.64E − 06

3.53E − 02

0.0238

5.37E − 05

7.75E − 01

cg13558971

1

203597085

ATP2B4

5′ UTR

− 0.0007

1.78E − 06

3.64E − 02

− 0.0092

1.82E − 03

8.17E − 01

cg13348877

18

78005237

PARD6G

1stExon

− 0.0002

2.01E − 06

3.93E − 02

− 0.0021

8.15E − 05

8.17E − 01

cg08996521

3

50649994

CISH

TSS1500

0.0005

2.52E − 06

4.70E − 02

0.0131

1.10E − 04

8.17E − 01

  1. aCpGs are located in the gene if no distance is indicated
  2. bBased on manifest feature annotation Illumina. IGR, intergenic region
  3. cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
  4. d p values and FDR corresponding to M values. Table is sorted on WC associated p values. All significant hits for both outcomes are included
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Clinical Epigenetics

ISSN: 1868-7083

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