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Table 3 Differentially methylated positions for WC and abdominal obesity (WC ≥ 88 cm for women and ≥ 102 cm for men)

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

      WC Abdominal obesity
CpG site CHR Position Nearest genea Featureb Delta
β valuec
p valued FDRd Delta
β valuec
p valued FDRd
cg07839457 16 57023022 NLRC5 TSS1500 0.0030 2.24E − 10 9.61E − 05 0.0340 6.86E − 05 8.17E − 01
cg00574958 11 68607622 CPT1A 5′ UTR − 0.0007 1.00E − 08 1.55E − 03 − 0.0135 1.52E − 08 6.54E − 03
cg25954539 6 31323677 HLA-B Body 0.0022 1.08E − 08 1.55E − 03 0.0316 5.78E − 05 7.75E − 01
cg08818207 6 32820355 TAP1 Body 0.0020 3.46E − 08 3.71E − 03 0.0303 5.14E − 05 7.75E − 01
cg04927537 17 76976091 LGALS3BP TSS200 0.0013 6.19E − 08 5.08E − 03 0.0195 4.23E − 05 7.75E − 01
cg22107533 15 45028083 TRIM69 TSS1500 0.0015 7.76E − 08 5.08E − 03 0.0252 2.14E − 04 8.17E − 01
cg01309328 6 32811253 PSMB8 Body 0.0014 8.69E − 08 5.08E − 03 0.0202 6.26E − 06 6.45E − 01
cg23533285 6 31322348 HLA-B Body 0.0015 9.47E − 08 5.08E − 03 0.0241 2.99E − 04 8.17E − 01
cg23570810 11 315102 IFITM1 Body 0.0018 1.12E − 07 5.35E − 03 0.0182 1.12E − 05 6.68E − 01
cg00218406 6 31431407 HCP5 3′ UTR 0.0022 1.66E − 07 7.12E − 03 0.0335 7.64E − 04 8.17E − 01
cg08099136 6 32811251 PSMB8 Body 0.0015 1.93E − 07 7.53E − 03 0.0180 3.23E − 04 8.17E − 01
cg11202345 17 76976057 LGALS3BP 1stExon 0.0011 2.15E − 07 7.70E − 03 0.0203 4.65E − 05 7.75E − 01
cg25178683 17 76976267 LGALS3BP TSS1500 0.0011 3.50E − 07 1.16E − 02 0.0136 1.41E − 05 6.68E − 01
cg01971407 11 313624 IFITM1 TSS1500 0.0010 4.69E − 07 1.44E − 02 0.0079 5.71E − 05 7.75E − 01
cg25843003 6 31431312 HCP5 3′ UTR 0.0009 7.03E − 07 2.01E − 02 0.0142 8.12E − 05 8.17E − 01
cg22940798 6 32805554 TAP2 Body 0.0010 1.03E − 06 2.75E − 02 0.0187 5.19E − 04 8.17E − 01
cg20399616 12 25055967 BCAT1 Body − 0.0012 1.20E − 06 2.97E − 02 − 0.0145 9.27E − 04 8.17E − 01
cg05439368 15 45028098 TRIM69 TSS1500 0.0015 1.25E − 06 2.97E − 02 0.0263 1.99E − 04 8.17E − 01
cg06538684 12 12511223 LOH12CR2 TSS1500 0.0011 1.62E − 06 3.53E − 02 0.0173 9.31E − 05 8.17E − 01
cg23235965 6 30459540 HLA-E Body 0.0011 1.64E − 06 3.53E − 02 0.0238 5.37E − 05 7.75E − 01
cg13558971 1 203597085 ATP2B4 5′ UTR − 0.0007 1.78E − 06 3.64E − 02 − 0.0092 1.82E − 03 8.17E − 01
cg13348877 18 78005237 PARD6G 1stExon − 0.0002 2.01E − 06 3.93E − 02 − 0.0021 8.15E − 05 8.17E − 01
cg08996521 3 50649994 CISH TSS1500 0.0005 2.52E − 06 4.70E − 02 0.0131 1.10E − 04 8.17E − 01
  1. aCpGs are located in the gene if no distance is indicated
  2. bBased on manifest feature annotation Illumina. IGR, intergenic region
  3. cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
  4. d p values and FDR corresponding to M values. Table is sorted on WC associated p values. All significant hits for both outcomes are included