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Table 2 Differentially methylated positions for BMI and obesity (BMI ≥ 30 kg/m2)

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

     

BMI

Obesity

CpG site

CHR

Position

Nearest genea

Featureb

Delta

β valuec

p valued

FDRd

Delta

β valuec

p valued

FDRd

cg07839457

16

57023022

NLRC5

TSS1500

0.0071

3.79E − 11

1.63E − 05

0.0711

6.38E − 09

1.37E − 03

cg08818207

6

32820355

TAP1

Body

0.0047

7.66E − 08

1.64E − 02

0.0440

5.61E − 06

2.67E − 01

cg00574958

11

68607622

CPT1A

5′ UTR

− 0.0014

1.45E − 07

1.71E − 02

− 0.0189

2.53E − 10

1.09E − 04

cg08099136

6

32811251

PSMB8

Body

0.0033

1.59E − 07

1.71E − 02

0.0321

1.18E − 04

6.62E − 01

cg01309328

6

32811253

PSMB8

Body

0.0029

3.38E − 07

2.91E − 02

0.0315

1.02E − 05

3.19E − 01

cg20399616

12

25055967

BCAT1

Body

− 0.0028

4.61E − 07

3.30E − 02

− 0.0297

6.36E − 08

9.10E − 03

cg22107533

15

45028083

TRIM69

TSS1500

0.0037

5.69E − 07

3.49E − 02

0.0330

7.10E − 05

6.41E − 01

cg06820412

5

135386296

TGFBI

Body

0.0005

7.22E − 07

3.81E − 02

0.0050

1.63E − 05

3.71E − 01

cg00218406

6

31431407

HCP5

3′ UTR

0.0051

8.03E − 07

3.81E − 02

0.0483

4.34E − 05

5.33E − 01

cg25954539

6

31323677

HLA-B

Body

0.0046

1.02E − 06

3.81E − 02

0.0454

2.70E − 05

4.15E − 01

cg23235965

6

30459540

HLA-E

Body

0.0026

1.04E − 06

3.81E − 02

0.0270

4.50E − 06

2.42E − 01

cg25178683

17

76976267

LGALS3BP

TSS1500

0.0019

1.08E − 06

3.81E − 02

0.0195

7.91E − 05

6.41E − 01

cg08996521

3

50649994

CISH

TSS1500

0.0015

1.26E − 06

3.81E − 02

0.0142

1.06E − 05

3.19E − 01

cg04927537

17

76976091

LGALS3BP

TSS200

0.0026

1.34E − 06

3.81E − 02

0.0286

6.46E − 06

2.76E − 01

cg05490029

8

79719015

IL7

TSS1500

0.0026

1.45E − 06

3.81E − 02

0.0244

1.80E − 05

3.71E − 01

cg18954700

10

124220854

HTRA1

TSS200

− 0.0015

1.49E − 06

3.81E − 02

− 0.0137

4.74E − 04

8.19E − 01

cg25843003

6

31431312

HCP5

3′ UTR

0.0021

1.51E − 06

3.81E − 02

0.0200

5.98E − 05

6.22E − 01

cg06118217

2

240100998

HDAC4

Body

0.0008

1.72E − 06

4.11E − 02

0.0069

1.11E − 05

3.19E − 01

  1. aCpGs are located in the gene if no distance is indicated
  2. bBased on manifest feature annotation Illumina. IGR, intergenic region
  3. cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
  4. d p values and FDR corresponding to M values. Table is sorted on BMI associated p values. All significant hits for both outcomes are included
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Clinical Epigenetics

ISSN: 1868-7083

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