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Table 2 Differentially methylated positions for BMI and obesity (BMI ≥ 30 kg/m2)

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

      BMI Obesity
CpG site CHR Position Nearest genea Featureb Delta
β valuec
p valued FDRd Delta
β valuec
p valued FDRd
cg07839457 16 57023022 NLRC5 TSS1500 0.0071 3.79E − 11 1.63E − 05 0.0711 6.38E − 09 1.37E − 03
cg08818207 6 32820355 TAP1 Body 0.0047 7.66E − 08 1.64E − 02 0.0440 5.61E − 06 2.67E − 01
cg00574958 11 68607622 CPT1A 5′ UTR − 0.0014 1.45E − 07 1.71E − 02 − 0.0189 2.53E − 10 1.09E − 04
cg08099136 6 32811251 PSMB8 Body 0.0033 1.59E − 07 1.71E − 02 0.0321 1.18E − 04 6.62E − 01
cg01309328 6 32811253 PSMB8 Body 0.0029 3.38E − 07 2.91E − 02 0.0315 1.02E − 05 3.19E − 01
cg20399616 12 25055967 BCAT1 Body − 0.0028 4.61E − 07 3.30E − 02 − 0.0297 6.36E − 08 9.10E − 03
cg22107533 15 45028083 TRIM69 TSS1500 0.0037 5.69E − 07 3.49E − 02 0.0330 7.10E − 05 6.41E − 01
cg06820412 5 135386296 TGFBI Body 0.0005 7.22E − 07 3.81E − 02 0.0050 1.63E − 05 3.71E − 01
cg00218406 6 31431407 HCP5 3′ UTR 0.0051 8.03E − 07 3.81E − 02 0.0483 4.34E − 05 5.33E − 01
cg25954539 6 31323677 HLA-B Body 0.0046 1.02E − 06 3.81E − 02 0.0454 2.70E − 05 4.15E − 01
cg23235965 6 30459540 HLA-E Body 0.0026 1.04E − 06 3.81E − 02 0.0270 4.50E − 06 2.42E − 01
cg25178683 17 76976267 LGALS3BP TSS1500 0.0019 1.08E − 06 3.81E − 02 0.0195 7.91E − 05 6.41E − 01
cg08996521 3 50649994 CISH TSS1500 0.0015 1.26E − 06 3.81E − 02 0.0142 1.06E − 05 3.19E − 01
cg04927537 17 76976091 LGALS3BP TSS200 0.0026 1.34E − 06 3.81E − 02 0.0286 6.46E − 06 2.76E − 01
cg05490029 8 79719015 IL7 TSS1500 0.0026 1.45E − 06 3.81E − 02 0.0244 1.80E − 05 3.71E − 01
cg18954700 10 124220854 HTRA1 TSS200 − 0.0015 1.49E − 06 3.81E − 02 − 0.0137 4.74E − 04 8.19E − 01
cg25843003 6 31431312 HCP5 3′ UTR 0.0021 1.51E − 06 3.81E − 02 0.0200 5.98E − 05 6.22E − 01
cg06118217 2 240100998 HDAC4 Body 0.0008 1.72E − 06 4.11E − 02 0.0069 1.11E − 05 3.19E − 01
  1. aCpGs are located in the gene if no distance is indicated
  2. bBased on manifest feature annotation Illumina. IGR, intergenic region
  3. cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
  4. d p values and FDR corresponding to M values. Table is sorted on BMI associated p values. All significant hits for both outcomes are included