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Table 2 CpG sites whose methylation are controlled by gout-associated GWAS SNPs

From: DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding

GWAS SNP

CpG

Chromosome

SNP position (hg19)

CpG position (hg19)

Gene close to the CpG site

P value (geno vs. meth)

rs780093

cg05102552

chr2

27742603

27650867

NRBP1

3.13E−12

rs13129697

cg00071950

chr4

9926967

10020882

SLC2A9

3.87E−12

rs3775948

cg00071950

chr4

9997112

10020882

SLC2A9

< 2E−16

rs717615

cg00071950

chr4

10104670

10020882

SLC2A9

< 2E−16

rs1165205

cg15691649

chr6

25870542

25882328

SLC17A3

< 2E−16

rs505802

cg19131476

chr11

64357072

64387923

NRXN2

< 2E−16