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Fig. 5 | Clinical Epigenetics

Fig. 5

From: DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding

Fig. 5

Proposed model for methylation-dependent TFAP2A binding and regulation of NRBP1 expression in gout. a In healthy subjects, TFAP2A binds to methylated B1, which suppresses the transcription of NRBP1. b In contrast, hypomethylation of B1 at the promoter region of NRBP1 abrogates TFAP2A binding, which results in elevated NRBP1 expression in gout

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