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Fig. 1 | Clinical Epigenetics

Fig. 1

From: DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding

Fig. 1

Identification of a gout risk gene and a potential TFAP2A binding site at its promoter region. a The association between a gout-associated GWAS SNP, rs780093, and DNA methylation level of cg05102552 from human peripheral blood mononuclear cells (PBMCs). Each dot represents an individual and average methylation level for each genotype group is indicated by red bar. Statistical significance for the association was evaluated with additive minor-allele dosage model and P value was indicated in the bottom. b Cg05102552 site is 552 bp upstream of NRBP1 transcription start site (TSS) and is in a region with DNase I hypersensitive sites (DHSs) and high level of active histone modifications, such as H3K4me1, H3K4me3, and H3K27Ac. The potential TFAP2A binding region, B1, was highlighted in the bottom

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