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Table 2 LncRNAs expression level and TKIs treatment resistance in lung cancer

From: Histone code and long non-coding RNAs (lncRNAs) aberrations in lung cancer: implications in the therapy response

lncRNA Possible targets Mechanism Drug Dysregulation status Lung cancer type Reference
UCA1 AKT/mTOR N/D TKIs Up NSCLC [78]
  N/I N/D Gefitinib Up NSCLC [85]
GAS5 IGR-1R N/D Gefitinib Down NSCLC [81]
MIR31HG EGFR/PI3K/AKT signaling pathway N/D Gefitinib Up NSCLC [84]
BC087858 PI3K/AKT, MEK/ERK N/D EGFR-TKIs Up NSCLC [82]
  N/I N/D Gefitinib Up NSCLC [80]
BC200 N/I N/D Gefitinib Up NSCLC [80]
HOTAIR N/I N/D Gefitinib Down NSCLC [80]
MALAT1 N/I N/D Gefitinib Down NSCLC [80]
ENST00000507437 N/I N/D Gefitinib Up NSCLC [80]
ENST00000508827 N/I N/D Gefitinib Up NSCLC [80]
NR_026685 N/I N/D Gefitinib Up NSCLC [80]
ENST00000381279 N/I N/D Gefitinib Down NSCLC [80]
ENST00000418077 N/I N/D Gefitinib Down NSCLC [80]
BG188549 N/I N/D Gefitinib Down NSCLC [80]
BE244504 N/I N/D Gefitinib Down NSCLC [80]
CASC9 N/I N/D Gefitinib Up NSCLC [85]
EWAST1 (LINC00277) N/I N/D Gefitinib Down NSCLC [85]
LINC00524 N/I N/D Gefitinib Down NSCLC [85]
  1. Up upregulated, Down downregulated, SCLC small-cell lung cancer, NSCLC non-small cell lung cancer, N/I non-identified, N/D non-determined