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Table 1 LncRNAs expression level and oncological treatment resistance in lung cancer

From: Histone code and long non-coding RNAs (lncRNAs) aberrations in lung cancer: implications in the therapy response

lncRNA

Possible targets

Mechanism

Drug

Dysregulation status

Lung cancer type

Reference

CUDR

Caspase 3

N/D

Doxorubicin/

Etoposide

Up

Squamous carcinoma

[68]

HOTAIR

p21

N/D

Cisplatinum

Up

NSCLC

[65]

 

HOXA1

DNA methylation

Multidrug resistance (Cisplatinum, Adriamycin, Etoposide)

Up

SCLC

[66]

 

Klf4

Promote stemness.

Cisplatinum

Up

NSCLC

[67]

AK126698

Wnt/β-catenin, NKD2

N/D

Cisplatinum

Down

NSCLC

[55]

MEG3

p53, Bcl-xl

N/D

Cisplatinum

Down

NSCLC

[62]

 

Wnt/β-catenin

N/D

Cisplatinum

Down

NSCLC

[69]

NEAT1

CTR1

N/D

Cisplatinum

Down

Adenocarcinoma

[70]

H19

N/D

N/D

Cisplatinum

Up

NSCLC

[73]

ROR

PI3K/AKT/mTOR

N/D

Cisplatinum

Up

NSCLC

[71]

 

EMT

N/D

Docetaxel

Up

NSCLC

[72]

CCAT1

let-7c

N/D

Docetaxel

Up

Adenocarcinoma

[75]

KCNQ1OT1

N/I

N/D

Paclitaxel

Up

NSCLC

[76]

TUG1

LIMK2b, EZH2

Promoter DNA methylation

Multidrug resistance (Cisplatinum, Adriamycin)

Up

SCLC

[74]

  1. Up upregulated, Down downregulated, SCLC small-cell lung cancer, NSCLC non-small cell lung cancer, N/D non-determined