Fig. 3

EGFR cell signaling and lncRNAs relationship in lung cancer therapy resistance. The binding of the EGF ligand to the EGFR receptor causes the autophosphorylation of the tyrosine residues located in the terminal COOH-domain, allowing the activation of multiple downstream signaling cascades through the recruitment of signaling proteins to the intracellular portion of the receptor including Ras/Raf/MEK/ERK, PI3K/Akt, JAK/STAT and PLC, which ultimately drive to proliferation, survival, and/or tumor cell invasion. Growth factor-stimulated "IGF-1R" also induces the activation of AKT and ERK signaling pathways. Likewise, the probable participation of lncRNAs along the EGFR cell signaling pathway has been indicated, as a new likely lncRNAs therapy targets in lung cancer