Fig. 3
From: Epigenetic response of imprinted domains during carcinogenesis
Bisulfite sequencing of the Peg3 imprinting control region. Each row represents an individual sequencing result from a clone. Each column represents a CpG site within the Peg3-ICR PCR product. The black boxes denote methylated CpG cites. The white boxes denote unmethylated CpG sites. The restriction enzyme digestion sites within the PCR products are marked with triangles: purple for HphI and red for TaqαI. Red coloration of the sample name/number indicates significant methylation changes detected by both COBRA and sequencing