Fig. 6
Mediation analysis for methylation prognostic signature through mRNA expression. a Diagram of mediation model. b Methylation signature from the seven CpG sites was treated as “exposure”; mediator was the linear combination of the corresponding seven genes’ expression level (scoreexpression) (Overall model). Total prognostic effect in hazard ratio (HR) were described as direct effect (HRdirect), indirect effect (HRindirect), corresponding 95% confidence interval (95% CI), and the proportion of effect mediated (M%). Further, sensitivity analyses were performed by excluding each gene from scoreexpression, respectively, which retained statistical significance for mediation effect