Fig. 5
Association between gene expression and methylation. Left panels show correlation of a AJAP1, b SHANK2, c FOXA2, d MT1A, e ZNF570, f HOXC4, and g HOXB4 expression (X-axis) with methylation (Y-axis). Right panels show Kaplan-Meier survival plots of gene expression from the TCGA cohort. HR indicates hazard ratio. Correlation coefficients and hypothesis tests were based on Spearman rank correlation tests. Patients were categorized into high-risk and low-risk groups by an optimum cutoff point according to the highest χ 2 value. h ROC curves for expression of the seven genes (left) and combinations of different types of data (right), including clinical characteristics (Clin), gene expression (Exp), and methylation (Methy)