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Fig. 7 | Clinical Epigenetics

Fig. 7

From: The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

Fig. 7

Cohesin plays a direct role in adipogenesis gene regulation. a RT-q-PCR analysis of gene expression changes in Nipbl+/− mutant MEFs and MEFs treated with siRNA against Nipbl and Rad21 (*p < 0.05, **p < 0.01). Cohesin-binding status is also shown. P: promoter, B: gene body, and D: downstream as in Fig. 5 with the exception of IL6. For IL6, the cohesin-binding site in the downstream region is 3 kb away from TSS. b A schematic diagram of genes involved in the adipogenesis pathway. Genes that changed expression in Nipbl+/− mutant MEFs are circled, and those bound by cohesin and examined in a are shown with shaded circles

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