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Fig. 6 | Clinical Epigenetics

Fig. 6

From: The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

Fig. 6

Cohesin-binding signals at specific gene regions. a Cohesin-binding site distribution in cohesin target genes as defined in Table 1. Cohesin binding to the promoter (P), gene body (B), and/or downstream region (D) are indicated for each cohesin target gene in red (upregulated) and blue (downregulated) boxes. b Signal intensity profiles of Rad21 ChIP-seq at specific gene regions in wild type and Nipbl mutant MEFs. Preimmune IgG ChIP-seq signals are shown as a negative control. Experimentally determined CTCF-binding peaks in MEFs [40] are also indicated. Examples of genes that are bound by cohesin and changed expression in Nipbl+/− MEFs (top) and those genes that did not change expression (bottom) are shown. No cohesin-binding peaks were found at the Srp14 gene region

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