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Fig. 4 | Clinical Epigenetics

Fig. 4

From: The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

Fig. 4

Cohesin-binding site distribution in the genome in MEFs. a Percentage distribution of cohesin peaks in genomic regions. “Promoter” and “Downstream” is defined as 2500 bp upstream of the transcription start site (TSS) and 500 bp downstream of the TSS, and “Downstream” represents 500 bp upstream of transcription termination site (TTS) and 2500 bp downstream of TTS. The 3′ and 5′ untranslated regions (UTRs) are defined as those annotated by the UCSC genome browser minus the 500 bp interior at either the TSS or TTS. When a peak overlaps with multiple regions, it is assigned to one region with the order of precedence of promoter, 5′ UTR, Intron, Exon, 3’UTR, downstream, and intergenic. b Enrichment of cohesin peaks across genomic regions as compared to randomly sampled genomic sequence. A comparable number of peaks (25,407 and 16,528 peaks in wild type and mutant MEFs, respectively), with the same length as the input set, were randomly chosen 1000 times and the average used as a baseline to determine enrichment in each genomic region category

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