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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas

Fig. 4

Treatment with inhibitors variably alters gene expression in all cell lines. Droplet digital PCR analysis of expressional ratios of nine target genes (EGFR, TP53, MKI67, CDKN2A, CCND1, MET, PTEN, PIK3CA, EZH2, ALDH1A1, and CD44) following 7-day treatment with GSK-343, DZNeP, or EPZ-5687. EEF2 was utilized as an internal reference, with exception to PTEN:PIK3CA as their gene products are directly antagonistic to one another. Scales vary according to individual expression results. SCC-9 cell line does not express CDKN2A and is therefore not pictured

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