Pyrosequencing quantified methylation level of miR-124 predicts shorter survival for patients with myelodysplastic syndrome

Table 2 Leukaemia-free survival of MDS patients with different miR-124 methylation levels at CpG sites by pyrosequencing

mir-124 genes	Cut-off values (%)	No. of patients		Leukaemia-free survival (months)		P
mir-124 genes	Cut-off values (%)	Low-meth	High-meth	Low-meth	High-meth	P
miR-124-1	7.4	43	13	36.3	12.3	0.029
miR-124-1-1	3.5	15	41	36.9	31.9	0.379
miR-124-1-2	4.5	15	41	40.6	25.2	0.148
miR-124-1-3	3.5	16	40	34.9	33.1	0.688
miR-124-1-4	8.5	44	12	36.6	5.5	0.010
miR-124-2	24.8	27	29	43.1	18.0	0.001
miR-124-2-1	11.5	23	33	40.3	23.5	0.058
miR-124-2-2	15	26	30	42.9	18.3	0.002
miR-124-2-3	19.5	35	21	37.2	18.0	0.083
miR-124-2-4	16.5	35	21	38.2	18.4	0.011
miR-124-2-5	30	24	32	44.7	18.0	0.001
miR-124-3	8.6	21	35	39.5	24.1	0.069
miR-124-3-1	13.5	42	14	35.2	12.5	0.271
miR-124-3-2	10.5	29	27	36.5	24.2	0.178
miR-124-3-3	4.5	17	39	32.1	30.1	0.302
miR-124-3-4	14.5	19	37	34.4	19.2	0.042
miR-124-3-5	9.0	31	25	36.9	24.0	0.119
miR-124-3-6	4.5	20	36	39.1	30.4	0.096
miR-124-3-7	7.5	29	27	36.4	30.8	0.279
miR-124-3-8	11.5	19	37	44.3	21.7	0.005
miR-124-3-9	8.5	36	20	35.6	21.0	0.254

ISSN: 1868-7083