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Table 4 Multiple range test did not show significant differences in the generated score between OSCC group and HGSIL group. Both groups showed significant higher values whether considering healthy donors or considering contralateral mucosa. Multiple range test showed a statistical difference between contralateral mucosa of OSCC and HGSIL patients and healthy donors

From: CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel

Method: 95.0% LSD

Pathology

Count

Mean

Homogeneous groups

 Healthy donors

65

−1.586

C

 Distant mucosa in OSCC patients

30

−0.444399

B

 OSCC

29

2.66856

A

 HGSIL

6

2.71892

A

Contrast

Sig.

Difference

± limits

 OSCC–HGSIL

 

−0.0503633

0.983538

 OSCC–distant mucosa in OSCC patients

*

3.11296

0.571081

 OSCC–healthy donors

*

4.25456

0.489711

 HGSIL–distant mucosa in OSCC patients

*

3.16332

0.980724

 HGSIL–healthy donors

*

4.30492

0.935683

 Distant mucosa in OSCC patients–healthy donors

*

1.1416

0.484034

  1. *Statistically significant difference