Epigenetic regulation of inflammation in localized aggressive periodontitis

Clinical Epigenetics

Table 1 Demographic and clinical parameters for all patients used in the analysis

	Age	Gender	PD (mm)	#PD > 6 mm	CAL (mm)	#CAL > 3 mm	% affected sites^a	% BoP	% plaque
Severe LAP	13.70 ± 3.74	1M/9F	5.85 ± 0.9**	4.80 ± 2.4^#	4.06 ± 1.24^#	13 ± 10.49^#	13.97 ± 8.54**	14.50 ± 9.54	45.60 ± 27
Moderate LAP	17.00 ± 2.21	5M/5F	5.38 ± 0.8**	1.60 ± 1.0	2.10 ± 0.45**	1.90 ± 1.14	8.30 ± 6.18**	14.20 ± 9.39	36.40 ± 17.85
HC	14.53 ± 5.39	8M/12F	2.74 ± 0.6	0	0	0	0	13.11 ± 9.44	22.84 ± 11.31

Means ± standard deviation. No statistical difference found between groups for gender, age, and BoP. Note: CAL value = 0 for healthy controls, as there is no attachment loss present in any site
LAP localized aggressive periodontitis, HC healthy controls/mild gingivitis (< 25% BoP and no radiographic bone loss or attachment loss), PD mean pocket depth of affected sites^a (PD ≥ 5 mm with CAL ≥ 2 mm and radiographic bone loss), CAL mean clinical attachment level of affected sites, BoP bleeding on probing, NA not applicable as healthy controls did not present sites PD ≥ 5 with CAL ≥ 2 mm
**p < 0.05 between LAP and HC; ^# p < 0.05 between severe vs moderate LAP and HC