Fig. 1
From: Epigenetic regulation of inflammation in localized aggressive periodontitis
DNA methylation levels of pro-inflammatory genes in periodontitis vs control subjects. ANOVA with Tukey’s comparisons or Kruskal-Wallis with Dunn’s comparisons were carried out among healthy controls (HC), localized aggressive moderate (Mod), and severe (Sev) periodontitis. ***p < 0.001, **p < 0.01, *p < 0.05. Note that severe aggressive periodontitis displays lower methylation levels in several genes when compared to moderate periodontitis, while moderate disease shows higher methylation levels in general. TLR-2 signaling genes that are pro-inflammatory: RIPK2 receptor-interacting serine/threonine-protein kinase 2(c), MP3K7 mitogen-activated protein kinase kinase kinase 7(b), MYD88 myeloid differentiation primary response gene 88(a), IL6R interleukin 6 receptor(d)