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Table 2 Single cfnucleosome AUC and sensitivity at 80% specificity

From: Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis

Nu.Q™ assay IPF (untreated) vs healthy
AUC % sensitivity at 80% specificity
mH2A1.1 0.85 86
5mC 0.83 78
HMGB1 0.81 74
H3K27Ac 0.79 74
H3K9Ac 0.77 61
H4K20Me3 0.70 50
pH2AX 0.66 39
H4Pan(Ac) 0.57 13
H3K4Me2 0.57 14
H3K9Me3 0.54 13
  1. cfnucleosome features between healthy subject (n = 27) and untreated (n = 23) idiopathic pulmonary fibrosis patients. The receiver operator characteristic (ROC) curve analysis is calculated at 80% specificity. All serum nucleosome modifications were analyzed by ELISA Nu.Q™ assays
  2. AUC area under the curve