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Table 1 Subject characteristics

From: Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis

  Healthy subjects
n = 27
Untreated IPF
n = 23
Treated IPF
n = 27
Age, years 60(9) 72(11)** 68(9)*
Gender (M/F) 14/13 20/3 19/8
Height, cm 170(9) 171(10) 170(9)
Weight, kg 74(12) 76(15) 78(10)
BMI, kg/m2 26(3) 26(4) 27(3)
Smokers (NS/FS/S) 6/17/4 6/13/4 7/20/0
FEV1 post-BD, %pred. 104(14) 75(14)*** 67(13)***
FVC post-BD, %pred. 112(20) 74(14)*** 66(16)***
FEV1/FVC post-BD, % 78(5) 78(11) 80(6)
TLC, %pred. nd 70(13) 68(15)
RV, %pred. nd 71(32) 82(27)
DLCO, %pred. nd 39(13) 38(13)
KCO, %pred. nd 62(13) 70(20)
ICS (yes/no) 0/27 1/22 0/27
OCS (yes/no) 0/27 0/23 0/27
Treatment with pirfenidone/nintedanib nd nd 18/9
  1. Data are expressed as mean (SD)
  2. nd not determined, NS non-smoker, FS former smoker, S smoker, FEV1 forced expired volume in one second, FVC forced vital capacity, TLC total lung capacity, DLCO diffusion lung capacity for CO, KCO DLCO/alveolar ventilation, ICS inhaled corticosteroids, OCS oral corticosteroids
  3. *p < 0.05, **p < 0.001, ***p < 0.0001 compared to healthy subjects