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Table 1 Epigenetic treatments in H358 cells

From: Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer

H358 cells

Epithelial genes

Mesenchymal genes

E-cadh

EpCAM

ESRP1

Rab25

ST14

N-cadh

NRP2

PD-L1

SEMA3C

Vim

ZEB1

Without TGF-β1

SAHA

2.51

  

1.70

0.0053

1.25

 

1.33

2.35

  

EPZ5676

       

0.69

 

0.675

 

SGC0946

  

1.66

1.19

       

PFI-1

0.73

 

0.56

0.65

0.85

  

0.26

0.28

  

SAHA + EPZ5676

3.01

   

0.24

1.52

0.33

1.40

0.20

  

SAHA + SGC0946

2.02

   

0.24

1.33

0.29

 

0.31

  

SAHA + PFI-1

1.25

 

0.25

0.51

0.0038

 

0.13

0.45

0.14

  

With TGF-β1

SAHA

3.90

  

3.36

0.0002

1.34

0.30

2.32

0.17

0.84

0.45

EPZ5676

    

0.0004

    

1.21

 

SGC0946

    

0.0016

0.86

  

1.43

  

PFI-1

  

0.18

 

0.21

0.71

0.15

0.27

0.03

0.58

0.26

SAHA + EPZ5676

2.83

  

3.00

0.0001

1.15

0.27

2.40

0.17

0.82

0.51

SAHA + SGC0946

3.74

  

4.42

0.27

1.25

0.32

1.91

0.18

0.82

0.39

SAHA + PFI-1

   

3.71

 

0.71

0.10

0.37

0.15

0.59

0.45

  1. Statistical significant results from Fig. 5 are summarized for variation of gene expression upon different treatments in absence or presence of TGF-β1, with the ratio of RT-qPCR values of treated cells/corresponding untreated control cells. Values above 1 (italics) indicate increased expression, and values under 1 indicate decreased expression
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Clinical Epigenetics

ISSN: 1868-7083

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