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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer

Fig. 6

H3K79 methylation pathway and potential therapeutic targets. Histone acetylation is recognized and bound by BET bromodomain proteins (e.g., BRD4) which induced the protein complex RNF20/RNF40/WAC activation and H2BK120 ubiquitination. DOT1L which activity is stimulated by H2BK120ub1 further methylates H3K79. BRD4 and DOT1L can be inhibited by PFI-1 and EPZ5676/SGC0946, respectively

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Clinical Epigenetics

ISSN: 1868-7083

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