Table 2 Major markers for lupus susceptibility and monitoring
Histone modification marker | Expression level of target gene | Clinical correlation and SLE disease association | Possible mechanisms | Ref. |
|---|---|---|---|---|
Histone methylation marker | ||||
 H3K4 trimethylation | ↑(PBMCs) | Positively correlated with disease severity | Several candidate genes related to SLE pathogenesis (such as PTPN22, LRP1B) are involved | [79] |
Histone acetylation marker | ||||
 H3K4 hypoacetylation | ↑(CD4+ T cell) | Positively correlated with disease severity |  | [117] |