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Table 3 Summary of CIs generated from the isobologram of increasing concentrations of chidamide and IDA, DNR, or Ara-C for CD34+CD38 KG1α cells

From: Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

Drugs (nM) FA Chidamide (μM) FAChidamide FAComb CI
IDA FAIDA     
 20 0.087 0.5 0.044 0.179 0.610
 20 0.087 0.75 0.049 0.242 0.481
 40 0.229 0.5 0.044 0.468 0.516
 40 0.229 0.75 0.049 0.693 0.291
DNR FADNR     
 100 0.053 0.5 0.041 0.142 0.149
 100 0.053 0.75 0.042 0.166 0.107
 200 0.077 0.5 0.041 0.274 0.069
 200 0.077 0.75 0.042 0.422 0.022
Ara-C FAAra-C     
 500 0.128 0.5 0.041 0.200 0.220
 500 0.128 0.75 0.042 0.212 0.177
 1000 0.157 0.5 0.041 0.235 0.244
 1000 0.157 0.75 0.042 0.304 0.089
  1. CI less than 1.0 indicates synergistic effect. FAChidamide indicates fraction of cytotoxicity by chidamide alone; FAIDA, FADNR, and FAAra-C, fraction of cytotoxicity by IDA, DNR, or Ara-C alone, respectively; FAComb fraction of cytotoxicity by chidamide plus IDA, DNR, or Ara-C