Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

Table 1 The clinical characteristic of AML patients (n = 12)

No.	Age/sex	Disease status	FAB subtype	WBC count(×10⁹/l)	Karyotype	Molecular features	LDH
1	48/M	Refractory	M0	4.11	46,XY	EGR1,CBFβ,MYH1,TP53	High
2	48/F	Refractory	M2b	5.0	46,XY	AML1/ETO	Normal
3	18/F	Refractory	M5b	39.79	46,XY	NPM1,TET2,ASXL1	Normal
4	26/F	Relapse	M0	124.7	46,XY	FLT3-ITD	Normal
5	52/F	Refractory	M2	1.54	Complex	MLL,EGFR	Normal
6	25/F	Refractory	M1	6.6	46,XY	CEBPa	High
7	46/F	Relapse	M2	37.85	46,XX,t(8,21)	AML1/ETO	High
8	23/M	Relapse	M0	1.97	46,XX	AML1/ETO	Normal
9	30/M	Refractory	M0	93.13	46,XX,t(8,21)	CBFβ,MYH1	High
10	42/M	Relapse	M2	33.48	Complex	c-kit	High
11	26/M	Refractory	M5b	5.37	Complex	CEBPa, MLL	High
12	54/M	Relapse	M4eo	79.0	Complex	CEBPa,KMT3A	Normal

M man, F female, FAB French-American-Britain, WBC white blood cell, LDH lactic dehydrogenase

ISSN: 1868-7083