Skip to main content

Advertisement

Table 5 Logistic Regression Model between vitamin B12 and folate levels and the risk of methylation of p16, MLH1, and MGMT at the 3rd tertile (%)

From: High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

  Vit B12 (pmol/L) Folates* (nmol/L)
<148 148–221 >45.3
p16 CpG
site
3a OR 0.70 0.36 1.97
95% CI 0.23–2.08 0.10–1.23 1.04–3.75
5b OR 0.46 0.67 4.17
95% CI 0.13–1.6 0.2–2.2 2.12–8.19
MLH1 1c OR 0.56 0.93 2.31
95% CI 0.14–2.19 0.28–3.13 1.15–4.64
2d OR 0.43 0.86 3.73
95% CI 0.10–1.88 0.26–2.90 1.83–7.59
3e OR 1.18 1.22 2.08
95% CI 0.34–4.13 0.38–3.95 1.03–4.20
Averagef OR 0.99 1.60 2.20
95% CI 0.26–3.80 0.48–5.32 1.08–4.50
MGMT 4g OR 0.96 0.12 3.91
95% CI 0.28–3.26 0.014–0.99 1.88–8.11
Averageh OR 0.92 0.6 2.84
95% CI 0.28–2.98 0.19–2.52 1.42–5.69
  1. Adjusted by sex, age, tobacco, BMI, Hcy, HoloTC, and MMA
  2. OR odd ratio, CI confidence interval
  3. *p < 0.05 vs folate <45.3 nmol/L
  4. a< 2.35% methylation
  5. b2.11% methylation
  6. c< 5.24% methylation
  7. d< 2.65% methylation
  8. e < 0.34% methylation
  9. f< 2.14% methylation
  10. g< 3.2% methylation
  11. h< 1.48% methylation