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Table 5 Logistic Regression Model between vitamin B12 and folate levels and the risk of methylation of p16, MLH1, and MGMT at the 3rd tertile (%)

From: High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

 

Vit B12 (pmol/L)

Folates* (nmol/L)

<148

148–221

>45.3

p16

CpG

site

3a

OR

0.70

0.36

1.97

95% CI

0.23–2.08

0.10–1.23

1.04–3.75

5b

OR

0.46

0.67

4.17

95% CI

0.13–1.6

0.2–2.2

2.12–8.19

MLH1

1c

OR

0.56

0.93

2.31

95% CI

0.14–2.19

0.28–3.13

1.15–4.64

2d

OR

0.43

0.86

3.73

95% CI

0.10–1.88

0.26–2.90

1.83–7.59

3e

OR

1.18

1.22

2.08

95% CI

0.34–4.13

0.38–3.95

1.03–4.20

Averagef

OR

0.99

1.60

2.20

95% CI

0.26–3.80

0.48–5.32

1.08–4.50

MGMT

4g

OR

0.96

0.12

3.91

95% CI

0.28–3.26

0.014–0.99

1.88–8.11

Averageh

OR

0.92

0.6

2.84

95% CI

0.28–2.98

0.19–2.52

1.42–5.69

  1. Adjusted by sex, age, tobacco, BMI, Hcy, HoloTC, and MMA
  2. OR odd ratio, CI confidence interval
  3. *p < 0.05 vs folate <45.3 nmol/L
  4. a< 2.35% methylation
  5. b2.11% methylation
  6. c< 5.24% methylation
  7. d< 2.65% methylation
  8. e < 0.34% methylation
  9. f< 2.14% methylation
  10. g< 3.2% methylation
  11. h< 1.48% methylation
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Clinical Epigenetics

ISSN: 1868-7083

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