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Table 4 Spearman correlation for blood concentrations of vitamins and metabolites and DNA methylation in specific CpG sites of LINE-1, p16, MLH1, and MGMT genes

From: High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

  CpG site Vit B12 n = 242 Folates n = 241 HoloTC n = 193 Hcy n = 193 MMA n = 193
LINE-1 1 −0.1064 0.0193 −0.1357 0.0509 0.0298
2 −0.0106 −0.1259 −0.0680 −0.0811 0.1004
3 0.1067 0.0360 0.1321 −0.0644 −0.0318
4 −0.0346 −0.0127 −0.1313 0.0281 0.0394
Average −0.0373 0.0302 −0.1135 0.0604 0.0166
p16 1 0.1888* 0.0156 0.1152 −0.0002 −0.0137
2 −0.0552 −0.1519 0.0104 −0.0239 −0.0303
3 0.2965* 0.2320* 0.1137 −0.1293 −0.1288
5 0.2198* 0.2974* 0.0595 −0.0462 −0.1619
6 −0.1668 −0.1787 −0.0167 0.0709 0.0449
7 0.0863 −0.1029 0.1230 0.0455 −0.0597
Average 0.2288* 0.0867 0.1553 −0.0880 −0.1318
MLH1 1 −0.2809* −0.1616 0.0360 −0.0555 −0.0634
2 0.0977 0.2453* −0.0248 −0.0422 −0.0656
3 −0.1404 −0.1102 −0.0374 −0.0393 −0.0451
4 0.1246 0.3121* 0.0399 −0.1387 −0.1486
Average −0.1081 0.1786* 0.0188 −0.1410 −0.1478
MGMT 1 0.1118 0.2291* −0.0167 −0.0589 −0.0211
2 0.3142* 0.4196* −0.0082 −0.0702 −0.1504
3 0.0791 0.2007* −0.0522 −0.0417 −0.0876
4 −0.1561 −0.3457* 0.0002 0.0808 0.1207
5 −0.1187 −0.1011 −0.0570 −0.0621 −0.0806
6 −0.0111 −0.0272 −0.0012 −0.1773 −0.1511
Average 0.1168 0.2489* −0.0591 −0.0567 −0.0474
  1. *p < 0.01