Table 4 Spearman correlation for blood concentrations of vitamins and metabolites and DNA methylation in specific CpG sites of LINE-1, p16, MLH1, and MGMT genes
|  | CpG site | Vit B12 n = 242 | Folates n = 241 | HoloTC n = 193 | Hcy n = 193 | MMA n = 193 |
|---|---|---|---|---|---|---|
LINE-1 | 1 | −0.1064 | 0.0193 | −0.1357 | 0.0509 | 0.0298 |
2 | −0.0106 | −0.1259 | −0.0680 | −0.0811 | 0.1004 | |
3 | 0.1067 | 0.0360 | 0.1321 | −0.0644 | −0.0318 | |
4 | −0.0346 | −0.0127 | −0.1313 | 0.0281 | 0.0394 | |
Average | −0.0373 | 0.0302 | −0.1135 | 0.0604 | 0.0166 | |
p16 | 1 | 0.1888* | 0.0156 | 0.1152 | −0.0002 | −0.0137 |
2 | −0.0552 | −0.1519 | 0.0104 | −0.0239 | −0.0303 | |
3 | 0.2965* | 0.2320* | 0.1137 | −0.1293 | −0.1288 | |
5 | 0.2198* | 0.2974* | 0.0595 | −0.0462 | −0.1619 | |
6 | −0.1668 | −0.1787 | −0.0167 | 0.0709 | 0.0449 | |
7 | 0.0863 | −0.1029 | 0.1230 | 0.0455 | −0.0597 | |
Average | 0.2288* | 0.0867 | 0.1553 | −0.0880 | −0.1318 | |
MLH1 | 1 | −0.2809* | −0.1616 | 0.0360 | −0.0555 | −0.0634 |
2 | 0.0977 | 0.2453* | −0.0248 | −0.0422 | −0.0656 | |
3 | −0.1404 | −0.1102 | −0.0374 | −0.0393 | −0.0451 | |
4 | 0.1246 | 0.3121* | 0.0399 | −0.1387 | −0.1486 | |
Average | −0.1081 | 0.1786* | 0.0188 | −0.1410 | −0.1478 | |
MGMT | 1 | 0.1118 | 0.2291* | −0.0167 | −0.0589 | −0.0211 |
2 | 0.3142* | 0.4196* | −0.0082 | −0.0702 | −0.1504 | |
3 | 0.0791 | 0.2007* | −0.0522 | −0.0417 | −0.0876 | |
4 | −0.1561 | −0.3457* | 0.0002 | 0.0808 | 0.1207 | |
5 | −0.1187 | −0.1011 | −0.0570 | −0.0621 | −0.0806 | |
6 | −0.0111 | −0.0272 | −0.0012 | −0.1773 | −0.1511 | |
Average | 0.1168 | 0.2489* | −0.0591 | −0.0567 | −0.0474 |