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Table 3 Associations of placental mtDNA methylation and content with cord blood thyroid hormones

From: Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

 

FT3, pmol/L

FT4, pmol/L

TSH, mU/L

Variable

β

(95% CI)

β

(95% CI)

β

(95% CI)

mtDNA methylationa

  MT-RNR1

-1.50

(-2.70 to -0.30)*

-0.60

(-1.04 to -0.16)*

0.38

(-0.21 to 0.97)

  D-loop

-0.46

(-0.83 to -0.09)*

-0.14

(-0.28 to -0.002)*

0.11

(-0.07 to 0.29)

mtDNA contentb

20.35

(0.47 to 44.17)*

11.04

(4.00 to 18.54)**

-5.34

(-13.35 to 3.40)

  1. aβ represents an absolute change in placental mtDNA methylation percentage (%) for a 10th-90th percentile increment of cord blood thyroid hormone
  2. bβ represents a relative change (%) in placental mtDNA content for a 10th-90th percentile increment of cord blood thyroid hormone
  3. All models are adjusted for maternal age, pre-pregnancy BMI, gestational age, newborn’s sex, smoking status, parity, maternal education, ethnicity, and cord plasma insulin level
  4. * p-value < 0.05, ** p-value < 0.005