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Table 3 Associations of placental mtDNA methylation and content with cord blood thyroid hormones

From: Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

  FT3, pmol/L FT4, pmol/L TSH, mU/L
Variable β (95% CI) β (95% CI) β (95% CI)
mtDNA methylationa
MT-RNR1 -1.50 (-2.70 to -0.30)* -0.60 (-1.04 to -0.16)* 0.38 (-0.21 to 0.97)
D-loop -0.46 (-0.83 to -0.09)* -0.14 (-0.28 to -0.002)* 0.11 (-0.07 to 0.29)
mtDNA contentb 20.35 (0.47 to 44.17)* 11.04 (4.00 to 18.54)** -5.34 (-13.35 to 3.40)
  1. aβ represents an absolute change in placental mtDNA methylation percentage (%) for a 10th-90th percentile increment of cord blood thyroid hormone
  2. bβ represents a relative change (%) in placental mtDNA content for a 10th-90th percentile increment of cord blood thyroid hormone
  3. All models are adjusted for maternal age, pre-pregnancy BMI, gestational age, newborn’s sex, smoking status, parity, maternal education, ethnicity, and cord plasma insulin level
  4. * p-value < 0.05, ** p-value < 0.005