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Table 2 Cord blood thyroid hormone levels and placental mtDNA content and mtDNA methylation

From: Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

 

Mean

SD

10th percentile

90th percentile

Thyroid hormonesa

 FT3, pmol/L

2.63

0.47

2.15

3.22

 FT4, pmol/L

15.66

2.08

13.26

18.53

 TSH, mU/L

11.65

7.60

5.16

20.59

mtDNA methylationb

  MT-RNR1, %

9.51

4.19

4.46

14.67

  D-loop, %

3.61

1.31

1.94

5.24

mtDNA content (unitless)b,c

1.11

0.96

0.49

2.49

  1. Values are presented as geometric means with 10th-90th percentiles, except for mtDNA methylation for which the arithmetic mean is given
  2. aLaboratory reference values for adults range from 4.0 to 6.8 pmol/L for FT3, from 12.0 to 21.9 pmol/L for FT4, and from 0.3 to 4.2 mIU/L for TSH
  3. bMeasured in placental tissue
  4. cDetermined as the ratio of two mitochondrial genes gene copy numbers (MTF3212/R3319 and MT-ND1) to two single-copy nuclear control genes (RPLP0 and ACTB)