Skip to main content

Table 2 Cord blood thyroid hormone levels and placental mtDNA content and mtDNA methylation

From: Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

  Mean SD 10th percentile 90th percentile
Thyroid hormonesa
 FT3, pmol/L 2.63 0.47 2.15 3.22
 FT4, pmol/L 15.66 2.08 13.26 18.53
 TSH, mU/L 11.65 7.60 5.16 20.59
mtDNA methylationb
MT-RNR1, % 9.51 4.19 4.46 14.67
D-loop, % 3.61 1.31 1.94 5.24
mtDNA content (unitless)b,c 1.11 0.96 0.49 2.49
  1. Values are presented as geometric means with 10th-90th percentiles, except for mtDNA methylation for which the arithmetic mean is given
  2. aLaboratory reference values for adults range from 4.0 to 6.8 pmol/L for FT3, from 12.0 to 21.9 pmol/L for FT4, and from 0.3 to 4.2 mIU/L for TSH
  3. bMeasured in placental tissue
  4. cDetermined as the ratio of two mitochondrial genes gene copy numbers (MTF3212/R3319 and MT-ND1) to two single-copy nuclear control genes (RPLP0 and ACTB)